Concepts of Genetics (12th Edition)
Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 24, Problem 1CS
Summary Introduction

To determine: The methods by which the participants can understand that the trial is for experimental purpose, and it is not directly intended to help the patient.

Introduction: Research is designed to analyze the effect of a particular condition or substance on a population. In the research, the people are mainly divided into two groups, one of the groups is provided with the condition that is according to experimental purpose, and the other group is used as a control. The grouping is highly randomized, and the researcher must be unbiased in selecting the group.

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. Consider a base substitution mutation that occurred in a DNA sequence that resulted in a change in the encoded protein from the amino acid glutamic acid to aspartic acid. Normally the glutamic acid amino acid is located on the outside of the soluble protein but not near an active site. O-H¨ A. What type of mutation occurred? O-H B. What 2 types of chemical bonds are found in the R-groups of each amino acid? The R groups are shaded. CH2 CH2 CH2 H2N-C-COOH H2N-C-COOH 1 H Glutamic acid H Aspartic acid C. What 2 types of bonds could each R-group of each of these amino acids form with other molecules? D. Consider the chemical properties of the two amino acids and the location of the amino acid in the protein. Explain what effect this mutation will have on this protein's function and why.
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Chapter 24 Solutions

Concepts of Genetics (12th Edition)

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