EBK MICROBIOLOGY
12th Edition
ISBN: 8220100659720
Author: CASE
Publisher: PEARSON
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Chapter 24, Problem 3MCQ
Summary Introduction
Introduction:
Mycoplasma pneumonia is gram positive bacteria, which has no peptidoglycan layer so it has the antibiotic resistance and also escapes from immune response by changing the cell membrane mimic to host, and it is detected by the PCR method. It is called as the walking pneumonia which occurs due to transmission of bacteria by means of aerosols.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 24 Solutions
EBK MICROBIOLOGY
Ch. 24 - DRAW IT Show the locations of the following...Ch. 24 - Compare and contrast mycoplasmal pneumonia and...Ch. 24 - Prob. 3RCh. 24 - Complete the following table.Ch. 24 - Under what conditions can the saprophytes...Ch. 24 - Prob. 6RCh. 24 - List the causative agent, mode of transmission,...Ch. 24 - Prob. 8RCh. 24 - Prob. 9RCh. 24 - Prob. 10R
Ch. 24 - Prob. 1MCQCh. 24 - No bacterial pathogen can be isolated from the...Ch. 24 - Prob. 3MCQCh. 24 - Match the following choices to the culture...Ch. 24 - Prob. 5MCQCh. 24 - Match the following choices to the culture...Ch. 24 - Prob. 7MCQCh. 24 - Prob. 8MCQCh. 24 - Prob. 9MCQCh. 24 - Prob. 10MCQCh. 24 - Prob. 1ACh. 24 - Prob. 2ACh. 24 - Prob. 3ACh. 24 - In August, a 24-year-old man from Virginia...Ch. 24 - Prob. 2CAECh. 24 - Prob. 3CAE
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