Fundamentals of Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134396026
Author: Frederic H. Martini, Judi L. Nath, Edwin F. Bartholomew
Publisher: PEARSON
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Chapter 24, Problem 38CP
What body systems may be affected by inadequate calcium ion absorption?
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Biopharmaceutics and Pharmacokinetics:Two-Compartment Model Instant Absorption Questions
SHOW ALL WORK, including equation used, variables used and each step to your solution, report your regression lines and axes names (with units if appropriate) :Calculate a-q
a) B1,
b) B2,
c) hybrid rate constant (1)
d) hybrid rate constant (2)
e) t1/2,dist
f) t1/2,elim
g) k10
h) k12
i) k21
j) initial concentration (C0)
k) central compartment volume (V1)
l) steady-state volume (Vss)
m) clearance (CL) AUC (0→10 min) using trapezoidal rule
n) AUC (20→30 min) using trapezoidal rule
o) AUCtail (AUC360→∞)
p) total AUC (using short cut method)
q) volume from AUC (VAUC)
Glitazones reduce insulin resistance by binding to a transcription factor in adipocytes, thereby reducing thesecretion of fatty acids. Glitazones are taken orally (in pill form). Using pharmacokinetic modeling, deriveequations to describe how the concentration of glitazones varies in the plasma as a function of time. Yourequations should be of the form: dCglitazone /dt = something, or dMglitazone /dt = something. Your model shouldinclude three compartments: the gut, the plasma, and the fatty tissues. Make sure to include a diagram thatillustrates your thinking, state all assumptions, and define your variables. Do not solve the equations.
Case Study—Ella
Review the case study and then answer Parts A through F.
Ella has a family history of diabetes. She wants to follow a healthful eating pattern that can lower her risk for developing this condition. Her dietitian recommends a goal of 450 to 600 kcal per meal and advises Ella to follow the Acceptable Macronutrient Distribution Range (AMDR) for carbohydrates and the Dietary Guidelines for Americans 2015-2020, which recommend limiting added sugar. She also recommends that Ella choose whole grains rather than processed grains. Ella decides to pack a lunch to take to work every day. This morning she’s making a sandwich for her lunch.
Categories of Sandwich Options (Top of the screen)
Breads
Spreads
Cheeses
Vegetables
Proteins
Specific food items to select
White Bread 6-inches
Honey Mustard
Provolone
LettuceTomatoBell Peppers
Turkey
Part A - Reading Nutrition Facts Panels for Total Kilocalories
How many total kilocalories are in Ella’s sandwich?
_____…
Chapter 24 Solutions
Fundamentals of Anatomy & Physiology (11th Edition)
Ch. 24 - Prob. 1CPCh. 24 - Prob. 2CPCh. 24 - Prob. 3CPCh. 24 - Prob. 4CPCh. 24 - Name the layers of the gastrointestinal tract...Ch. 24 - Which is more efficient in propelling intestinal...Ch. 24 - Prob. 7CPCh. 24 - Prob. 8CPCh. 24 - Prob. 9CPCh. 24 - Prob. 10CP
Ch. 24 - Prob. 11CPCh. 24 - Prob. 12CPCh. 24 - Prob. 13CPCh. 24 - Name the structure connecting the pharynx to the...Ch. 24 - Prob. 15CPCh. 24 - Identify the muscles associated with the pharynx...Ch. 24 - What is occurring when the soft palate and larynx...Ch. 24 - Name the four major regions of the stomach.Ch. 24 - Prob. 19CPCh. 24 - Prob. 20CPCh. 24 - Prob. 21CPCh. 24 - The digestion of which nutrient would be most...Ch. 24 - Prob. 23CPCh. 24 - Prob. 24CPCh. 24 - Name the three regions of the small intestine from...Ch. 24 - Prob. 26CPCh. 24 - Prob. 27CPCh. 24 - How would the pH of the intestinal contents be...Ch. 24 - Prob. 29CPCh. 24 - Name some major histological differences between...Ch. 24 - Prob. 31CPCh. 24 - Prob. 32CPCh. 24 - Prob. 33CPCh. 24 - Prob. 34CPCh. 24 - Prob. 35CPCh. 24 - Prob. 36CPCh. 24 - Prob. 37CPCh. 24 - What body systems may be affected by inadequate...Ch. 24 - The enzymatic breakdown of large molecules into...Ch. 24 - Prob. 2RQCh. 24 - Prob. 3RQCh. 24 - Prob. 4RQCh. 24 - Prob. 5RQCh. 24 - Prob. 6RQCh. 24 - Prob. 7RQCh. 24 - Prob. 8RQCh. 24 - Prob. 9RQCh. 24 - Prob. 10RQCh. 24 - Prob. 11RQCh. 24 - Prob. 12RQCh. 24 - Prob. 13RQCh. 24 - Prob. 14RQCh. 24 - Prob. 15RQCh. 24 - What three basic mechanisms regulate the...Ch. 24 - Prob. 17RQCh. 24 - What are the primary digestive functions of the...Ch. 24 - Prob. 19RQCh. 24 - What are the three primary functions of the large...Ch. 24 - What two positive feedback loops are involved in...Ch. 24 - Prob. 22RQCh. 24 - Prob. 23RQCh. 24 - Prob. 24RQCh. 24 - Through which layers of a molar would an oral...Ch. 24 - Prob. 26RQCh. 24 - Prob. 27RQCh. 24 - Prob. 28RQCh. 24 - Some people with gallstones develop pancreatitis....Ch. 24 - Prob. 30RQCh. 24 - A condition known as lactose intolerance is...Ch. 24 - Prob. 32RQCh. 24 - Prob. 1CCCh. 24 - Prob. 2CC
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- Biopharmaceutics and Pharmacokinetics:Two-Compartment Model Instant Absorption Questions Calculate these : a) B1, b) B2, c) hybrid rate constant (1) d) hybrid rate constant (2) e) t1/2,dist f) t1/2,elim g) k10 h) k12 i) k21 j) initial concentration (C0) k) central compartment volume (V1) l) steady-state volume (Vss) m) clearance (CL) AUC (0→10 min) using trapezoidal rule n) AUC (20→30 min) using trapezoidal rule o) AUCtail (AUC360→∞) p) total AUC (using short cut method) q) volume from AUC (VAUC)arrow_forwardIn a population of Jackalopes (pictured below), horn length will vary between 0.5 and 2 feet, with the mean length somewhere around 1.05 feet. You pick Jackalopes that have horn lengths around 1.75 feet to breed as this appears to be the optimal length for battling other Jackalopes for food. After a round of breeding, you measure the offsprings' mean horn length is 1.67. What is the heritability of horns length (h2)? Is Jackalope horn length a heritable trait? (4 pts)? 12pt v R Paragraph V BIU A श्र > Barrow_forwardThere are many differences between DNA replication happening during mitosis in a Douglas fir tree growing in the Oregon Cascade Mountains and DNA replication happening during a PCR reaction in a forestry research lab at Oregon State University where the laboratory is amplifying a Simple Sequence Repeat. Complete the following table that compares the two DNA replication events in terms of the primers, the nucleotides, the polymerase, and the target sequence. Additionally, give a general value for the number of copies of the template DNA after one S phase in one cell and after the lab has completed the PCR reaction. Tree SSR Type your answer here: Primers Nucleotides Polymerase Target sequence Number of copiesarrow_forward
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