EBK BIOCHEMISTRY
EBK BIOCHEMISTRY
6th Edition
ISBN: 9781337431200
Author: GRISHAM
Publisher: CENGAGE LEARNING - CONSIGNMENT
bartleby

Concept explainers

bartleby

Videos

Question
Book Icon
Chapter 24, Problem 24P
Interpretation Introduction

Interpretation:

Using the active model for HMG-CoA reductase (HMGR), how HMGR is regulated and why do researchers seek ways to inhibit HMGR should be explained.

Concept Introduction:

HMG-CoA reductase is the rate controlling enzyme of mevalonate pathway which is the pathway for cholesterol and another isoprenoid biosynthesis. HGMR has eight domains and it is embedded in endoplasmic reticulum membrane. Today most of the cholesterol lowering drugs targets this enzyme. HMGR catalyzes the formation of mevalonic acid.

Blurred answer
Students have asked these similar questions
please draw it for me and tell me where i need to modify the structure
Please help determine the standard curve for my Kinase Activity in Excel Spreadsheet. Link: https://mnscu-my.sharepoint.com/personal/vi2163ss_go_minnstate_edu/_layouts/15/Doc.aspx?sourcedoc=%7B958f5aee-aabd-45d7-9f7e-380002892ee0%7D&action=default&slrid=9b178ea1-b025-8000-6e3f-1cbfb0aaef90&originalPath=aHR0cHM6Ly9tbnNjdS1teS5zaGFyZXBvaW50LmNvbS86eDovZy9wZXJzb25hbC92aTIxNjNzc19nb19taW5uc3RhdGVfZWR1L0VlNWFqNVc5cXRkRm4zNDRBQUtKTHVBQldtcEtWSUdNVmtJMkoxQzl3dmtPVlE_cnRpbWU9eEE2X291ZHIzVWc&CID=e2126631-9922-4cc5-b5d3-54c7007a756f&_SRM=0:G:93 Determine the amount of VRK1 is present 1. Average the data and calculate the mean absorbance for each concentration/dilution (Please over look for Corrections) 2. Blank Correction à Subtract 0 ug/mL blank absorbance from all readings  (Please over look for Corrections) 3. Plot the Standard Curve  (Please over look for Corrections) 4. Convert VRK1 concentration from ug/mL to g/L  5. Use the molar mass of VRK1 to convert to M and uM…
Macmillan Learning Cholesterol synthesis begins with the formation of mevalonate from acetyl CoA. This process activates mevalonate and converts it to isopentenyl pyrophosphate. Identify the atoms in mevalonate and isopentenyl pyrophosphate that will be labeled from acetyl CoA labeled with 14C in the carbonyl carbon. Place 14C atoms and C atoms to denote which carbon atoms are labeled and which are not labeled. H₂C COA 14C-labeled acetyl-CoA HHH [c] H H OH 014C - OH H HH H Mevalonate CH3 H H 14C H Η H H Incorrect Answer of o -P-O-P-0- Isopentenyl pyrophosphate с Answer Bank 14C
Knowledge Booster
Background pattern image
Biochemistry
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.
Similar questions
SEE MORE QUESTIONS
Recommended textbooks for you
Text book image
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
Text book image
Human Physiology: From Cells to Systems (MindTap ...
Biology
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Cengage Learning
Text book image
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Text book image
Biology: The Dynamic Science (MindTap Course List)
Biology
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Cengage Learning
Text book image
Concepts of Biology
Biology
ISBN:9781938168116
Author:Samantha Fowler, Rebecca Roush, James Wise
Publisher:OpenStax College
Text book image
Basic Clinical Laboratory Techniques 6E
Biology
ISBN:9781133893943
Author:ESTRIDGE
Publisher:Cengage
Metabolic Pathways; Author: Wisc-Online;https://www.youtube.com/watch?v=m61bQYio9ys;License: Standard Youtube License