Microbiology with Diseases by Body System (4th Edition)
4th Edition
ISBN: 9780321918550
Author: Robert W. Bauman Ph.D.
Publisher: PEARSON
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Chapter 24, Problem 1M
Match the term with its description.
- 1. ____ Dysuria
- 2. ____ Bacteremia
- 3. ____ Zoonosis
- 4. ____ Ophthalmia neonatorum
- 5. ____ Proctitis
- 6. ____ Pyelonephritis
- 7. ____ Orchitis
- 8. ____ Gummas
- 9. ____ Myalgia
- 10. ____ Cystitis
- 11. ____ Whitlow
- 12. ____ Prostatitis
- 13. ____ Condylomata acuminata
- 14. ____ PID
- 15. ____ Venereal disease
- A. Inflammation of a kidney
- B. Inflammation of the prostate
- C. Inflammation of the urinary bladder
- D. Inflammation of a testis
- E. Inflammation of the rectum
- F. Frequent, urgent, and painful urination
- G. Muscle pain
- H. Inflammation of the conjunctiva in newborns
- I. Disease spread from animals to humans
- J. Rubbery, painfully swollen lesions in bones, nervous tissue, or on the skin
- K. Large cauliflower-like growths on the genitalia
- L. General term for an STD
- M. Infection of skin by herpesviruses
- N. Bacterial invasion of the bloodstream
- ○. Inflammation of uterus, uterine tubes, and ovaries
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 24 Solutions
Microbiology with Diseases by Body System (4th Edition)
Ch. 24 - Why are newborn girls less likely to contract...Ch. 24 - Why does insertion of a urinary catheter increase...Ch. 24 - Why does Candida albicans, which is a member of...Ch. 24 - Prob. 4TMWCh. 24 - Prob. 1CCSCh. 24 - Why is erythromycin substituted for tetracycline...Ch. 24 - Prob. 2CCSCh. 24 - Prob. 6TMWCh. 24 - Prob. 3CCSCh. 24 - Prob. 4CCS
Ch. 24 - Prob. 7TMWCh. 24 - The functional unit of a kidney is the ________....Ch. 24 - Prob. 2MCCh. 24 - Prob. 3MCCh. 24 - Prob. 4MCCh. 24 - Prob. 5MCCh. 24 - Prob. 6MCCh. 24 - Prob. 7MCCh. 24 - Prob. 8MCCh. 24 - Prob. 9MCCh. 24 - Which of the following statements concerning...Ch. 24 - Match the term with its description. 1. ____...Ch. 24 - Prob. 2MCh. 24 - Prob. 1FIBCh. 24 - Prob. 2FIBCh. 24 - Prob. 3FIBCh. 24 - Prob. 4FIBCh. 24 - Prob. 5FIBCh. 24 - Prob. 6FIBCh. 24 - ____ Toxic shock syndrome is a sexually...Ch. 24 - Prob. 2MTFCh. 24 - Prob. 3MTFCh. 24 - __________ The symptoms of gonorrhea in women are...Ch. 24 - Prob. 5MTFCh. 24 - Prob. 6MTFCh. 24 - Prob. 7MTFCh. 24 - Prob. 8MTFCh. 24 - Prob. 9MTFCh. 24 - Prob. 10MTFCh. 24 - Prob. 11MTFCh. 24 - Prob. 1SACh. 24 - Prob. 2SACh. 24 - Prob. 3SACh. 24 - The Smith family gets cold sores regularly....Ch. 24 - Prob. 5SACh. 24 - Prob. 6SACh. 24 - Prob. 7SACh. 24 - Prob. 8SACh. 24 - Prob. 9SACh. 24 - Prob. 10SACh. 24 - Prob. 11SACh. 24 - Prob. 12SACh. 24 - Prob. 13SACh. 24 - Contrast vaginosis with vaginitis.Ch. 24 - Prob. 1VICh. 24 - Prob. 2VICh. 24 - Prob. 1CTCh. 24 - Some scientists think that syphilis is a New World...Ch. 24 - Prob. 3CTCh. 24 - Prob. 4CTCh. 24 - After a patient complains that his eyes are...Ch. 24 - Fifteen-year-old Dolores was embarrassed to talk...Ch. 24 - Prob. 7CTCh. 24 - Prob. 8CTCh. 24 - Prob. 9CTCh. 24 - Prob. 1CM
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