Chapter 24, Problem 11P

Interpretation Introduction

Interpretation:

The number of ATP equivalents needed to perform palmitic acid from acetyl CoA should be determined.

Concept Introduction:

The steps in the synthesis of palmitoyl CoA and the synthesis of malonyl CoA are as follows:

  $7{\text{ Acetyl-CoA + 7 HCO}}_3^{-}{\text{ + 7 ATP}}^{4-}\to {\text{ 7 malonyl-CoA}}^{-}{\text{ + 7 ADP}}^{3-}{\text{ + 7 P}}_i^{2-}{\text{ + 7 H}}^{+}$

  $\begin{array}{c}{\text{Acetyl-CoA + 7 malonyl-CoA}}^{-}{\text{ + 14 NADPH + 14 H}}^{+}\to {\text{ palmitoyl-CoA + 7 HCO}}_3^{-}\\ {\text{+ 14 NADP}}^{+}\\ \text{ + 7 CoASH}\end{array}$

The overall reaction for the synthesis of palmitoyl CoA from acetyl CoA is,

  $\begin{array}{l}{\text{8 Acetyl-CoA + 7 ATP}}^{4-}{\text{ + 14 NADPH + 7 H}}^{+}\to \\ {\text{ palmitoyl-CoA + 14 NADP}}^{+}{\text{ + 7 CoASH + 7 ADP}}^{3-}{\text{ + 7 P}}_i^2\end{array}$