7th Edition

ISBN: 9780321803221

Author: Paula Y. Bruice

Publisher: Prentice Hall

Concept explainers

A class of organic compounds needed in the human body for normal activities is known as vitamins. They are characterized into two parts depending upon their solubility in water. They can act as coenzymes, cofactors, or prosthetic groups for enzymes.

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Textbook Question

Chapter 23.9, Problem 17P

Carboxypeptidase A has esterase activity as well as peptidase activity, so it can hydrolyze ester bonds as well as peptide bonds. When carboxypeptidase A hydrolyzes ester bonds. Glu 270 acts as a nucleophilic catalyst instead of a general-base catalyst. Propose a mechanism for the carboxypeptidase A-catalyzed hydrolysis of an ester bond.

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Chapter 23.9, Problem 16P

Chapter 23.9, Problem 18P

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Chapter 23 Solutions

Organic Chemistry

Ch. 23.2 - Compare each of the mechanisms listed here with...Ch. 23.2 - Prob. 3P Ch. 23.2 - Prob. 4P Ch. 23.3 - a. Draw the mechanism for the following reaction...Ch. 23.5 - Prob. 7P Ch. 23.5 - Propose a mechanism for the Co2+ catalyzed...Ch. 23.6 - Prob. 9P Ch. 23.7 - Prob. 10P Ch. 23.7 - Prob. 12P Ch. 23.7 - Prob. 13P

Ch. 23.9 - Which of the following amino acid side chains can...Ch. 23.9 - Which of the following C-terminal peptide bonds is...Ch. 23.9 - Carboxypeptidase A has esterase activity as well...Ch. 23.9 - Arginine and lysine side chains fit into trypsins...Ch. 23.9 - Explain why serine proteases do not catalyze...Ch. 23.10 - If H2 18O is used in the hydrolysis reaction...Ch. 23.10 - When apples that have been cut are exposed to...Ch. 23.11 - Prob. 22P Ch. 23.11 - The pHactivity profile for glucose-6-phosphate...Ch. 23.11 - Draw the pH-activity profile for an enzyme that...Ch. 23.12 - Prob. 25P Ch. 23.12 - Draw the mechanism for the hydroxide ion-catalyzed...Ch. 23.12 - What advantage does the enzyme gain by forming an...Ch. 23.12 - Prob. 28P Ch. 23.12 - Aldolase shows no activity if it is incubated with...Ch. 23 - Which of the following parameters would be...Ch. 23 - Prob. 30P Ch. 23 - Prob. 31P Ch. 23 - Prob. 32P Ch. 23 - Indicate the type of catalysis that is occurring...Ch. 23 - The deuterium kinetic isotope effect (KH2O/KD2O)...Ch. 23 - Prob. 35P Ch. 23 - Co2+ catalyzes the hydrolysis of the lactam shown...Ch. 23 - there are two kinds of aldolases. Class I...Ch. 23 - Prob. 38P Ch. 23 - The hydrolysis of the ester shown here is...Ch. 23 - Prob. 40P Ch. 23 - At pH = 12, the rate of hydrolysis of ester A is...Ch. 23 - 2-Acetoxycyclohexyl tosylate reacts with acetate...Ch. 23 - Proof that an imine was formed between aldolase...Ch. 23 - Prob. 44P Ch. 23 - a. Explain why the alkyl halide shown here reacts...Ch. 23 - Triosephosphate isomerase (TIM) catalyzes the...

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