ANATOMY+PHYSIOLOGY(LL)-W/CONNECT ACCESS
4th Edition
ISBN: 9781266364051
Author: McKinley
Publisher: MCG
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Chapter 23.3, Problem 12WDYL
Which of the following respiratory structures are supported by cartilage: nose, larynx, trachea, bronchi, bronchioles, and alveolar sacs?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 23 Solutions
ANATOMY+PHYSIOLOGY(LL)-W/CONNECT ACCESS
Ch. 23.1 - Which respiratory structure is associated with the...Ch. 23.1 - Prob. 2WDYLCh. 23.1 - In what ways does the epithelium of the upper...Ch. 23.2 - What changes occur to inhaled air as it passes...Ch. 23.2 - Prob. 5WDYLCh. 23.2 - What two regions of the pharynx contain tonsils?...Ch. 23.2 - How does the larynx assist in increasing abdominal...Ch. 23.2 - What are the three unpaired cartilages in the...Ch. 23.2 - Prob. 9WDYLCh. 23.3 - What is the function of the C-shaped tracheal...
Ch. 23.3 - What are the significant structural differences...Ch. 23.3 - Which of the following respiratory structures are...Ch. 23.3 - The respiratory tract can be damaged from...Ch. 23.3 - Prob. 14WDYLCh. 23.3 - Prob. 15WDYLCh. 23.4 - Match the component of the ling with its air...Ch. 23.4 - Prob. 17WDYLCh. 23.4 - What is the function of serous fluid within the...Ch. 23.4 - Why is the intrapleural pressure normally lower...Ch. 23.5 - Prob. 20WDYLCh. 23.5 - Describe the sequence of events of quiet...Ch. 23.5 - How are larger amounts of air moved between the...Ch. 23.5 - Prob. 23WDYLCh. 23.5 - Which of the following stimuli will cause an...Ch. 23.5 - Are the skeletal muscles of breathing innervated...Ch. 23.5 - The two factors that determine airflow are the...Ch. 23.5 - A person in yoga class is encouraged to take long,...Ch. 23.5 - Prob. 28WDYLCh. 23.6 - Given the same partial pressure for oxygen and...Ch. 23.6 - How do the partial pressures of oxygen and carbon...Ch. 23.6 - Prob. 31WDYLCh. 23.6 - How do the partial pressures of oxygen and carbon...Ch. 23.7 - Why is such a small percentage (about 2%) of...Ch. 23.7 - How is the majority of carbon dioxide transported...Ch. 23.7 - How does oxygen movement occur during alveolar gas...Ch. 23.7 - How does carbon dioxide movement occur during...Ch. 23.7 - Does hemoglobin saturation increase or decrease...Ch. 23.7 - How is oxygen release from hemoglobin during...Ch. 23.8 - How does blood PO2 and PCO2 change if an...Ch. 23.8 - How does blood PO2 and PCO2 change during...Ch. 23.8 - Prob. 41WDYLCh. 23 - Prob. 1DYKBCh. 23 - Prob. 2DYKBCh. 23 - Prob. 3DYKBCh. 23 - Prob. 4DYKBCh. 23 - Prob. 5DYKBCh. 23 - Which areas of the brain contain the respiratory...Ch. 23 - Prob. 7DYKBCh. 23 - Prob. 8DYKBCh. 23 - Prob. 9DYKBCh. 23 - Prob. 10DYKBCh. 23 - Explain how the respiratory tract is organized...Ch. 23 - Describe the relationship of the visceral pleura,...Ch. 23 - List the four processes of respiration, in order,...Ch. 23 - Describe the muscles, volume changes, and pressure...Ch. 23 - Explain how additional air is moved during a...Ch. 23 - Describe bow quiet breathing is controlled by the...Ch. 23 - Explain alveolar and systemic gas exchange.Ch. 23 - List the two means by which oxygen is transported...Ch. 23 - Describe the relationship of PCO2 and hemoglobin...Ch. 23 - List the variables that increase the release of...Ch. 23 - Paramedics arrived at a car accident to find an...Ch. 23 - Use the following to answer questions 24....Ch. 23 - Use the following to answer questions 24....Ch. 23 - Use the following to answer questions 24....Ch. 23 - Prob. 5CALCh. 23 - Prob. 1CSLCh. 23 - The nerve to the sternocleidomastoid muscle was...Ch. 23 - Prob. 3CSL
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Respiratory System; Author: Amoeba Sisters;https://www.youtube.com/watch?v=v_j-LD2YEqg;License: Standard youtube license