EBK HUMAN ANATOMY & PHYSIOLOGY
1st Edition
ISBN: 9780100659834
Author: AMERMAN
Publisher: YUZU
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Textbook Question
Chapter 23.2, Problem 1QC
How do substrate-level phosphorylation and oxidative phosphorylation differ?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
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Chapter 23 Solutions
EBK HUMAN ANATOMY & PHYSIOLOGY
Ch. 23.1 - 1. How do catabolism and anabolism differ?
Ch. 23.1 - Prob. 2QCCh. 23.1 - 3. How do endergonic and exergonic reactions...Ch. 23.1 - Why are endergonic and exergonic reactions...Ch. 23.1 - Prob. 5QCCh. 23.1 - How does ATP fuel cellular processes?Ch. 23.1 - 7. In an oxidation-reduction reaction, what...Ch. 23.1 - 8. What is electron affinity? Do electrons flow...Ch. 23.1 - What is the electromotive force?Ch. 23.2 - How do substrate-level phosphorylation and...
Ch. 23.2 - What is glycolytic catabolism? Why is it also...Ch. 23.2 - Prob. 3QCCh. 23.2 - Prob. 4QCCh. 23.2 - Prob. 5QCCh. 23.2 - 6. Why is it important to regenerate NAD+ under...Ch. 23.2 - 7. What products are generated by the citric acid...Ch. 23.2 - Prob. 8QCCh. 23.2 - What is the potential energy in the bonds of...Ch. 23.3 - Prob. 1QCCh. 23.3 - Prob. 2QCCh. 23.3 - Prob. 3QCCh. 23.3 - Prob. 4QCCh. 23.3 - Why must the body eliminate the ammonia that...Ch. 23.4 - 1. How is glucose stored in the body?
Ch. 23.4 -
2. Which molecules can be used by the body for...Ch. 23.4 - Prob. 3QCCh. 23.4 - How are nonlipids converted into fats?Ch. 23.4 - Prob. 5QCCh. 23.4 - Prob. 6QCCh. 23.5 - 1. Why does anabolism dominate in the absorptive...Ch. 23.5 - Prob. 2QCCh. 23.5 - Prob. 3QCCh. 23.5 - Prob. 4QCCh. 23.5 - Prob. 5QCCh. 23.5 - 6. How do the actions of leptin differ from those...Ch. 23.6 - Prob. 1QCCh. 23.6 - Prob. 2QCCh. 23.6 - Prob. 3QCCh. 23.6 - Prob. 4QCCh. 23.6 - Prob. 5QCCh. 23.6 - Prob. 6QCCh. 23.6 - Prob. 7QCCh. 23.6 - Prob. 8QCCh. 23.7 - Prob. 1QCCh. 23.7 - Prob. 2QCCh. 23.7 - Prob. 3QCCh. 23.7 - Prob. 4QCCh. 23.7 - Prob. 5QCCh. 23.7 - Prob. 6QCCh. 23.7 - Prob. 7QCCh. 23.7 - Why is HDL considered good cholesterol, whereas...Ch. 23.7 - Prob. 9QCCh. 23.7 - Prob. 10QCCh. 23.7 - Prob. 11QCCh. 23 - Which of the following statements is false? a....Ch. 23 - Prob. 2CYRCh. 23 - Fill in the blanks: A/an ________reaction releases...Ch. 23 - Mark the following statements as true or false. If...Ch. 23 - Prob. 5CYRCh. 23 - Place the following events of glucose catabolism...Ch. 23 - Which of the following statements is false? a....Ch. 23 - Prob. 8CYRCh. 23 - Prob. 9CYRCh. 23 - Prob. 10CYRCh. 23 - Prob. 11CYRCh. 23 - Prob. 12CYRCh. 23 - Prob. 13CYRCh. 23 - Prob. 14CYRCh. 23 - Prob. 15CYRCh. 23 - Prob. 16CYRCh. 23 - Prob. 17CYRCh. 23 - Prob. 18CYRCh. 23 - Prob. 19CYRCh. 23 - 20. Which of the following statements is false?
a....Ch. 23 - Prob. 21CYRCh. 23 - Prob. 22CYRCh. 23 - Prob. 1CYUCh. 23 - Prob. 2CYUCh. 23 - Prob. 3CYUCh. 23 - Prob. 4CYUCh. 23 - People with extremely restricted caloric intake...Ch. 23 - Prob. 1AYKACh. 23 - Prob. 2AYKACh. 23 - 3. Certain dietary supplements for weight loss...Ch. 23 - Prob. 4AYKBCh. 23 - Prob. 5AYKB
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