Genetics: A Conceptual Approach 6E w/ SaplingPlus (Six-Month Access)
Genetics: A Conceptual Approach 6E w/ SaplingPlus (Six-Month Access)
6th Edition
ISBN: 9781319125929
Author: Benjamin A. Pierce
Publisher: W. H. Freeman
Question
Book Icon
Chapter 23.1, Problem 3TPSQ

a.

Summary Introduction

To determine:

The probability that another child of the couple will have retinoblastoma.

Introduction:

Alfred Knudson in 1971, proposed a model to explain the genetic basis for cancer. He was studying retinoblastoma (develops in one eye but sometimes appears in both) and proposed that retinoblastoma results from separate genetic defects mainly two and both of which are required for the development of cancer. Mutations in the cells of a single eye results in “unilateral retinoblastoma” which is common and can occur to a normal person.

Mutations in the cells of both eyes result in “bilateral retinoblastoma” which is rare and cannot happen randomly like unilateral retinoblastoma. Individuals inherit the only single mutation from suffering relatives and if the second mutation occurs in any of these cells then it would result in bilateral retinoblastoma.

b.

Summary Introduction

To determine:

Whether the next child has unilateral or bilateral retinoblastoma.

Introduction:

Alfred Knudson in 1971, proposed a model to explain the genetic basis for cancer. He was studying retinoblastoma (develops in one eye but sometimes appears in both) and proposed that retinoblastoma results from separate genetic defects mainly two and both of which are required for the development of cancer. Mutations in the cells of a single eye results in “unilateral retinoblastoma” which is common and can occur to a normal person.

Mutations in the cells of both eyes result in “bilateral retinoblastoma” which is rare and cannot happen randomly like unilateral retinoblastoma. Individuals inherit the only single mutation from suffering relatives and if the second mutation occurs in any of these cells then it would result in bilateral retinoblastoma.

c.

Summary Introduction

To determine:

The reason corresponding to that father has unilateral retinoblastoma while in his son’s and brother’s case it is bilateral retinoblastoma.

Introduction:

Alfred Knudson in 1971, proposed a model to explain the genetic basis for cancer. He was studying retinoblastoma (develops in one eye but sometimes appears in both) and proposed that retinoblastoma results from separate genetic defects mainly two and both of which are required for the development of cancer. Mutations in the cells of a single eye results in “unilateral retinoblastoma” which is common and can occur to a normal person.

Mutations in the cells of both eyes result in “bilateral retinoblastoma” which is rare and cannot happen randomly like unilateral retinoblastoma. Individuals inherit the only single mutation from suffering relatives and if the second mutation occurs in any of these cells then it would result in bilateral retinoblastoma.

Blurred answer
Students have asked these similar questions
You aim to test the hypothesis that the Tbx4 and Tbx5 genes inhibit each other's expression during limb development. With access to chicken embryos and viruses capable of overexpressing Tbx4 and Tbx5, describe an experiment to investigate whether these genes suppress each other's expression in the limb buds. What results would you expect if they do repress each other? What results would you expect if they do not repress each other?
You decide to delete Fgf4 and Fgf8 specifically in the limb bud. Explain why you would not knock out these genes in the entire embryo instead.
You implant an FGF10-coated bead into the anterior flank of a chicken embryo, directly below the level of the wing bud. What is the phenotype of the resulting ectopic limb?  Briefly describe the expected expression domains of 1) Shh, 2) Tbx4, and 3) Tbx5 in the resulting ectopic limb bud.
Knowledge Booster
Background pattern image
Similar questions
SEE MORE QUESTIONS
Recommended textbooks for you
Text book image
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:PEARSON
Text book image
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Text book image
Anatomy & Physiology
Biology
ISBN:9781259398629
Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:Mcgraw Hill Education,
Text book image
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:9780815344322
Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:W. W. Norton & Company
Text book image
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:9781260159363
Author:Martin, Terry R., Prentice-craver, Cynthia
Publisher:McGraw-Hill Publishing Co.
Text book image
Inquiry Into Life (16th Edition)
Biology
ISBN:9781260231700
Author:Sylvia S. Mader, Michael Windelspecht
Publisher:McGraw Hill Education