The consequences of a deficiency in vitamin B 1 2 for fatty acid oxidation and metabolic intermediate might accumulate should be explained. Concept Introduction: The final product of ß oxidation of fatty acids with odd number of carbon is 3-C propionyl CoA instead of acetyl CoA. Then propionyl CoA is converted into succinyl CoA via several steps. The carboxylation of a propionyl CoA to produce D-methylmalonyl CoA is the first step. The catalyst for the reaction is a biotin dependent enzyme propionyl CoA carboxylase. In the next step, D-methylmalonyl CoA so formed is isomerized into L-isomer by methylmalonyl CoA epimerase. This product is then subjected to methylmalonyl CoA mutase reaction which catalyzes the conversion of L-methylmalonyl CoA into succinyl CoA. This enzyme is vitamin B 1 2 dependent.

Question

what are the different classes and some examples of neuroprotectants that can be used to treat, prevent, or combat neurotoxicity/a neurotoxicant...for example, antioxidants, nutraceuticals, etc.,..?

Answer 1

Question

Chapter 23, Problem 7P

Interpretation Introduction

Interpretation:

The consequences of a deficiency in vitamin B₁₂for fatty acid oxidation and metabolic intermediate might accumulate should be explained.

Concept Introduction:

The final product of ß oxidation of fatty acids with odd number of carbon is 3-C propionyl CoA instead of acetyl CoA. Then propionyl CoA is converted into succinyl CoA via several steps.

The carboxylation of a propionyl CoA to produce D-methylmalonyl CoA is the first step. The catalyst for the reaction is a biotin dependent enzyme propionyl CoA carboxylase. In the next step, D-methylmalonyl CoA so formed is isomerized into L-isomer by methylmalonyl CoA epimerase.

This product is then subjected to methylmalonyl CoA mutase reaction which catalyzes the conversion of L-methylmalonyl CoA into succinyl CoA. This enzyme is vitamin B₁₂ dependent.

Expert Solution & Answer

Trending nowThis is a popular solution!

See solution

Check out sample textbook solution

Students have asked these similar questions

what are the different classes and some examples of neuroprotectants that can be used to treat, prevent, or combat neurotoxicity/a neurotoxicant...for example, antioxidants, nutraceuticals, etc.,..?

Imagine that aldolase can react with the seven carbon molecule Sedoheptulose-1,7-bisphosphate (below). Use the mechanism to predict the two products generated. Please draw out the stereochemistry in a fischer projection.

Sodium borohydride (NaBH4) is a potent inhibitor of aldolase. It is known to ONLY inhibit theenzyme when it is complexed with substrate. Treatment of the enzyme alone has no effect.What is the mechanism for this inhibition? Please draw out the mechanism and show how it inhibits this.