Human Anatomy (9th Edition)
9th Edition
ISBN: 9780134320762
Author: Frederic H. Martini, Robert B. Tallitsch, Judi L. Nath
Publisher: PEARSON
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Chapter 23, Problem 6RFT
Summary Introduction
To review:
Match the term NK cells with the most closely related description given below:
Rapid secondary response.
Responsible for cell-mediated immunity,
Produce antibodies.
Aid in immune surveillance.
Contains developing T cells.
Immunoglobulins.
Responsible for antibody-mediated immunity.
Production of lymphocytes.
Saclike chamber of the thoracic duct.
Largest lymphatic organ in the body.
Introduction:
Natural killer (NK) cells are one of the types of the lymphocyte, which generate the cytotoxic response against the pathogen molecules. Further, a majority of the times, these NK cells play a role analogous to that of the T cells.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 23 Solutions
Human Anatomy (9th Edition)
Ch. 23 - Match each numbered item with the most closely...Ch. 23 - Match each numbered item with the most closely...Ch. 23 - Prob. 3RFTCh. 23 - Prob. 4RFTCh. 23 - Prob. 5RFTCh. 23 - Prob. 6RFTCh. 23 - Prob. 7RFTCh. 23 - Match each numbered item with the most closely...Ch. 23 - Prob. 9RFTCh. 23 - Prob. 10RFT
Ch. 23 - Identify the structures of the lymphatic system in...Ch. 23 - The lymphatic system is composed of (a) lymphatic...Ch. 23 - Prob. 13RFTCh. 23 - 14. Most of the lymph returns to the venous...Ch. 23 - Prob. 15RFTCh. 23 - Prob. 16RFTCh. 23 - Prob. 17RFTCh. 23 - Prob. 18RFTCh. 23 - Prob. 19RFTCh. 23 - Prob. 20RFTCh. 23 - Prob. 21RFTCh. 23 - Prob. 1RCCh. 23 - Prob. 2RCCh. 23 - Blocking the antigen receptors on the surface of...Ch. 23 - Prob. 4RCCh. 23 - 5. What major artery and vein pass through the...Ch. 23 - Prob. 6RCCh. 23 - Prob. 7RCCh. 23 - Prob. 8RCCh. 23 - 9. What occurs in secondary lymphatic structures?
Ch. 23 - 10. Where are aggregated lymphoid nodules, also...Ch. 23 - Prob. 1CTCh. 23 - Prob. 2CTCh. 23 - Prob. 3CT
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