Concept explainers
(a)
Interpretation:
The effect of PAN on archaeal proteasome activity in the absence of nucleotides should be determined.
Concept introduction:
Proteasomes are the protein complexes; whose function is to degrade the damaged proteins by the process of proteolysis. Proteolysis process breaks the peptide bonds between the amino acids. Further, the enzymes that help in this process is termed as proteases. In eukaryotes, proteasomes are found in the nucleus and cytoplasm of the cell.
(b)
Interpretation:
The
Concept introduction:
Proteasomes are the protein complexes; whose function is to degrade the damaged proteins by the process of proteolysis. Proteolysis process breaks the peptide bonds between the amino acids. Further, the enzyme that helps in this process is termed as proteases. In eukaryotes, proteasomes are found in the nucleus and cytoplasm of the cell.
(c)
Interpretation:
The evidences that suggest that ATP hydrolysis is required for proteolysis, not just the presence of ATP, should be determined.
Concept introduction:
Proteasomes are the protein complexes; whose function is to degrade the damaged proteins by the process of proteolysis. Proteolysis process breaks the peptide bonds between the amino acids. Further, the enzyme that helps in this process is termed as proteases. In eukaryotes, proteasomes are found in the nucleus and cytoplasm of the cell.
(d)
Interpretation:
The reason for differences in peptide digestion and protein digestion should be determined.
Concept introduction:
Proteasomes are the protein complexes; whose function is to degrade the damaged proteins by the process of proteolysis. Proteolysis process breaks the peptide bonds between the amino acids. Further, the enzyme that helps in this process is termed as proteases. In eukaryotes, proteasomes are found in the nucleus and cytoplasm of the cell.
(e)
Interpretation:
The reason for the differences between protein digestion and peptide digestion should be determined.
Concept introduction:
Proteasomes are the protein complexes; whose function is to degrade the damaged proteins by the process of proteolysis. Proteolysis process breaks the peptide bonds between the amino acids. Further, the enzyme that helps in this process is termed as proteases. In eukaryotes, proteasomes are found in the nucleus and cytoplasm of the cell.
(f)
Interpretation:
If Thermoplasma PAN can augment protein digestion by proteasomes from other organisms should be determined.
Concept introduction:
Proteasomes are the protein complexes; whose function is to degrade the damaged proteins by the process of proteolysis. Proteolysis process breaks the peptide bonds between the amino acids. Further, the enzyme that helps in this process is termed as proteases. In eukaryotes, proteasomes are found in the nucleus and cytoplasm of the cell.
(g)
Interpretation:
The significance of the stimulation of the stimulation of rabbit muscle proteasome by Thermoplasma PAN should be determined.
Concept introduction:
Proteasomes are the protein complexes; whose function is to degrade the damaged proteins by the process of proteolysis. Proteolysis process breaks the peptide bonds between the amino acids. Further, the enzyme that helps in this process is termed as proteases. In eukaryotes, proteasomes are found in the nucleus and cytoplasm of the cell.
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Chapter 23 Solutions
BIOCHEMISTRY W/1 TERM ACHEIVE ACCESS
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- Help me understand how carbon disulfide leads to toxicity in the brain, using terms like distal axonopathy, neurofilaments, covalent cross-linking, adducts, etc.,...please intuitively explain what is happening and where and the effects of it. For example, I know that CS2 reacts with amide and sulfhydryl groups on proteins, but what proteins exactly and where are they located?arrow_forwardWhat is the standard free energy change (in kJ/mole) of the spontaneous reaction between Oxygen and NADH to form H2O2 and NAD+?arrow_forwardRedox Chemistry: Give standard free energy changes expected for the following reactions:-Succinate -> fumarate (using FAD/FADH2)-Oxaloacetate -> Malate (using NAD/NADH)-NADH --> NAD+ (using FMN/FMNH2)-CoQ --> CoQH2 (using Cytochrome C)arrow_forward
- Give examples of balanced redox reactions that match the following:-Catabolic-Anabolic-Oxidative-Reductivearrow_forwardIf there are 20uM of a GLUT2 transporter on the surface of a cell, each able to move 8 per second, and 50mM glucose outside of the cell, what is the flux into the cell in mM/sec?arrow_forwardA transporter is responsible for antiporting calcium and glucose. The transporter brings glucose into the cell and sends calcium out of the cell. If blood [calcium] = 2.55mM and intracellular [calcium] = 7uM, blood [glucose] = 5.2mM, and intracellular [glucose] = 40uM, what is the free energy of transport? Assume a membrane potential of 62mV (negative inside).arrow_forward
- An ATP-coupled transporter is used to import 1 phosphate from the extracellular environment. Intracellular phosphate exists at 65mM, while it is 2mM outside.Assume a free energy change of ATP hydrolysis of -42.7 kJ/mol. What is the net free energy change of the coupled reaction? Assume a membrane potential of 70mV.arrow_forwardAnother transporter brings 3 chloride ions into the cell. Outside, chloride has a concentration of 107mM, and 4mM inside the cell. Assuming a membrane potential of 62mV (negative inside), what is the free energy of transport of these ions?arrow_forwardFor the Oxaloacetate -> Malate reaction, assume the normal ratio of NAD/NADH, what is the maximum ratio of Malate/Oxaloacetate that will allow reaction progress?arrow_forward
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