BIOLOGY:THE ESSENTIALS (LL) W/CONNECT
3rd Edition
ISBN: 9781260670929
Author: Hoefnagels
Publisher: MCG CUSTOM
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Chapter 23, Problem 2PIT
Summary Introduction
To determine:
The name of 11 organ systems.
Introduction:
When a group of organs functions together as a biological system, it is known as an organ system. A human body is composed of 11 organs systems. Each organ system is assigned a specific task in the body and consists of certain tissues.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 23 Solutions
BIOLOGY:THE ESSENTIALS (LL) W/CONNECT
Ch. 23.1 - Prob. 1MCCh. 23.1 - Prob. 2MCCh. 23.2 - If you were given a microscope slide with a slice...Ch. 23.2 - Prob. 2MCCh. 23.3 - Which organ systems contribute to each of the five...Ch. 23.3 - Prob. 2MCCh. 23.4 - Use figure 23.7 to explain which materials enter...Ch. 23.4 - Prob. 2MCCh. 23.5 - Describe the difference between endotherms and...Ch. 23.5 - Prob. 2MC
Ch. 23 - Which of the following represents the correct...Ch. 23 - Prob. 2MCQCh. 23 - Prob. 3MCQCh. 23 - Blood differs from other types of connective...Ch. 23 - Prob. 5MCQCh. 23 - Prob. 6MCQCh. 23 - Prob. 7MCQCh. 23 - Prob. 8MCQCh. 23 - Prob. 9MCQCh. 23 - Distinguish between the following pairs of terms....Ch. 23 - Where do epithelial tissues occur, and how are...Ch. 23 - List and describe six types of connective tissue.Ch. 23 - Prob. 4WIOCh. 23 - Prob. 5WIOCh. 23 - Use the Internet to research cosmetic surgery....Ch. 23 - Prob. 7WIOCh. 23 - Prob. 8WIOCh. 23 - Make a chart that compares and contrasts the...Ch. 23 - Prob. 10WIOCh. 23 - Prob. 11WIOCh. 23 - Prob. 12WIOCh. 23 - Prob. 13WIOCh. 23 - Prob. 14WIOCh. 23 - Would an alligator require more, less, or the same...Ch. 23 - Prob. 16WIOCh. 23 - Prob. 17WIOCh. 23 - Prob. 1SLCh. 23 - Prob. 1PITCh. 23 - Prob. 2PITCh. 23 - Prob. 3PIT
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