Organic Chemistry
Organic Chemistry
12th Edition
ISBN: 9781118875766
Author: T. W. Graham Solomons, Craig B. Fryhle, Scott A. Snyder
Publisher: WILEY
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Chapter 23, Problem 2LGP

The biosynthesis of fatty acids is accomplished two carbons at a time by an enzyme complex called fatty acid synthetase. The biochemical reactions involved in fatty acid synthesis are described in Special Topic G (WileyPLUS). Each of these biochemical reactions has a counter-part in synthetic reactions you have studied. Consider the biochemical reactions involved in adding each −- C H 2 C H 2 −- segment during fatty acid biosynthesis (those in Special Topic G that begin with acetyl-S-ACP and malonyl-S-ACP, and end with butyryl-S-ACP). Write laboratory synthetic reactions using reagents and conditions you have studied (not biosynthetic reactions) that would accomplish the same sequence of transformations (i.e., the condensation–decarboxylation, ketone reduction, dehydration, and alkene reduction steps).

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