Microbiology with Diseases by Taxonomy (5th Edition)
5th Edition
ISBN: 9780134019192
Author: Robert W. Bauman Ph.D.
Publisher: PEARSON
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Chapter 23, Problem 2CT
Explain how each of the following could lead to the reemergence of malaria in the United States: (a) global warming, (b) increased travel of individuals from endemic regions to the United States, (c) increased immigration of individuals from endemic regions to the United States, (d) regulations against the use of insecticides, and (e) laws protecting wetlands.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 23 Solutions
Microbiology with Diseases by Taxonomy (5th Edition)
Ch. 23 - Parasitology is the study of parasitic _______. a....Ch. 23 - Prob. 2MCCh. 23 - Prob. 3MCCh. 23 - Prob. 4MCCh. 23 - Prob. 5MCCh. 23 - Prob. 6MCCh. 23 - The definitive host for Toxoplasma gondii...Ch. 23 - Prob. 8MCCh. 23 - Cryptosporidium cannot be killed by routine...Ch. 23 - Prob. 10MC
Ch. 23 - Prob. 11MCCh. 23 - Prob. 12MCCh. 23 - The infective larvae of Necator americanus must...Ch. 23 - Plasmodium species as well as Wuchereria bancrofti...Ch. 23 - Prob. 15MCCh. 23 - Prob. 16MCCh. 23 - Prob. 17MCCh. 23 - Prob. 18MCCh. 23 - Prob. 19MCCh. 23 - Prob. 20MCCh. 23 - Modified True/False Mark each Statement as true or...Ch. 23 - Prob. 2TFCh. 23 - Modified True/False Mark each Statement as true or...Ch. 23 - Prob. 4TFCh. 23 - Modified True/False Mark each Statement as true or...Ch. 23 - Prob. 6TFCh. 23 - Prob. 7TFCh. 23 - Prob. 8TFCh. 23 - Prob. 9TFCh. 23 - Mark each Statement as true or false. Rewrite the...Ch. 23 - Prob. 1MCh. 23 - Prob. 1VICh. 23 - Prob. 2VICh. 23 - Prob. 1SACh. 23 - How is the transmission of the amoeba Entamoeba...Ch. 23 - Compare Entamoeba, Acanthamoeba, and Naegleria....Ch. 23 - Explain how each of the following could lead to...Ch. 23 - People who suffer from AIDS are severely...Ch. 23 - Discuss why sickle-cell trait is advantageous to...Ch. 23 - Present a logical argument to explain the...Ch. 23 - What feature of the life cycle of T brucei makes...Ch. 23 - On July 10, a man in Palm Beach, Florida, was...Ch. 23 - A Peace Corps volunteer was evacuated from Malawi...Ch. 23 - Humans can accidentally become intermediate hosts...Ch. 23 - Using the following terms, fill in the following...Ch. 23 - A 20-year-old student was admitted to his colleges...Ch. 23 - Prob. 2CCSCh. 23 - Prob. 3CCSCh. 23 - Prob. 1TMWCh. 23 - Prob. 2TMWCh. 23 - Why are diseases of Entamoeba, Balantidium, and...Ch. 23 - Prob. 4TMWCh. 23 - Prob. 1EDCSCh. 23 - Prob. 2EDCS
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