The missing reagents and the structure of compound A in the synthesis of tamoxifen are to be determined. Concept introduction: The grignard reagent is prepared by the reaction of alkyl or aryl bromide with magnesium metal in the presence of ether. The reaction of the grignard reagent with an aldehyde / ketone followed by hydrolysis yields alcohol. Oxidation reaction involves an increase in the C − X bonds (where X usually is oxygen or a halogen atom) or decrease in the C − H bonds and vice versa for the reduction reaction.

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Chapter 23, Problem 25P

Interpretation Introduction

Interpretation:

The missing reagents and the structure of compound A in the synthesis of tamoxifen are to be determined.

Concept introduction:

The grignard reagent is prepared by the reaction of alkyl or aryl bromide with magnesium metal in the presence of ether.

The reaction of the grignard reagent with an aldehyde/ketone followed by hydrolysis yields alcohol.

Oxidation reaction involves an increase in the C−X bonds (where X usually is oxygen or a halogen atom) or decrease in the C−H bonds and vice versa for the reduction reaction.

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