(a) Interpretation: The compound, N - ( s e c -butyl ) - N -ethylaniline from chlorobenzene is to be synthesized. Concept introduction: Butchwald-Hatwig amination is the reaction in which aryl halides are directly aminated in the presence of a base and a catalyst to form aryl amines. The palladium catalyst is used in this reaction is PdL 2 , where, L stands for ligand. The mechanism of this reaction includes oxidative addition and reductive elimination.

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Answer 1

Question

Chapter 23, Problem 23.37P

Interpretation Introduction

(a)

Interpretation:

The compound, N-(sec-butyl)-N-ethylaniline from chlorobenzene is to be synthesized.

Concept introduction:

Butchwald-Hatwig amination is the reaction in which aryl halides are directly aminated in the presence of a base and a catalyst to form aryl amines. The palladium catalyst is used in this reaction is PdL2, where, L stands for ligand. The mechanism of this reaction includes oxidative addition and reductive elimination.

Interpretation Introduction

(b)

Interpretation:

The compound, 4-(4-tert-butylphenyl)morpholine from phenol is to be synthesized.

Concept introduction:

Butchwald-Hatwig amination is the reaction in which aryl halides are directly aminated in the presence of a base and a catalyst to form aryl amines. The catalyst used in this reaction is of the form PdL2, where, L stands for ligand. The mechanism of this reaction includes oxidative addition and reductive elimination.

Interpretation Introduction

(c)

Interpretation:

The compound, phenyl(4-(phenylamino)phenyl)methane from chlorobenzene is to be synthesized.

Concept introduction:

Butchwald-Hatwig amination is the reaction in which aryl halides are directly aminated in the presence of a base and a catalyst to form aryl amines. The catalyst used in this reaction is of the form PdL2, where, L stands for ligand. The mechanism of this reaction includes oxidative addition and reductive elimination. AlCl3

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Answer 2

Question

Chapter 23, Problem 23.37P

Interpretation Introduction

(a)

Interpretation:

The compound, N-(sec-butyl)-N-ethylaniline from chlorobenzene is to be synthesized.

Concept introduction:

Butchwald-Hatwig amination is the reaction in which aryl halides are directly aminated in the presence of a base and a catalyst to form aryl amines. The palladium catalyst is used in this reaction is PdL2, where, L stands for ligand. The mechanism of this reaction includes oxidative addition and reductive elimination.

Interpretation Introduction

(b)

Interpretation:

The compound, 4-(4-tert-butylphenyl)morpholine from phenol is to be synthesized.

Concept introduction:

Butchwald-Hatwig amination is the reaction in which aryl halides are directly aminated in the presence of a base and a catalyst to form aryl amines. The catalyst used in this reaction is of the form PdL2, where, L stands for ligand. The mechanism of this reaction includes oxidative addition and reductive elimination.

Interpretation Introduction

(c)

Interpretation:

The compound, phenyl(4-(phenylamino)phenyl)methane from chlorobenzene is to be synthesized.

Concept introduction:

Butchwald-Hatwig amination is the reaction in which aryl halides are directly aminated in the presence of a base and a catalyst to form aryl amines. The catalyst used in this reaction is of the form PdL2, where, L stands for ligand. The mechanism of this reaction includes oxidative addition and reductive elimination. AlCl3

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Answer 3

Question

Chapter 23, Problem 23.37P

Interpretation Introduction

(a)

Interpretation:

The compound, N-(sec-butyl)-N-ethylaniline from chlorobenzene is to be synthesized.

Concept introduction:

Butchwald-Hatwig amination is the reaction in which aryl halides are directly aminated in the presence of a base and a catalyst to form aryl amines. The palladium catalyst is used in this reaction is PdL2, where, L stands for ligand. The mechanism of this reaction includes oxidative addition and reductive elimination.

Interpretation Introduction

(b)

Interpretation:

The compound, 4-(4-tert-butylphenyl)morpholine from phenol is to be synthesized.

Concept introduction:

Butchwald-Hatwig amination is the reaction in which aryl halides are directly aminated in the presence of a base and a catalyst to form aryl amines. The catalyst used in this reaction is of the form PdL2, where, L stands for ligand. The mechanism of this reaction includes oxidative addition and reductive elimination.

Interpretation Introduction

(c)

Interpretation:

The compound, phenyl(4-(phenylamino)phenyl)methane from chlorobenzene is to be synthesized.

Concept introduction:

Butchwald-Hatwig amination is the reaction in which aryl halides are directly aminated in the presence of a base and a catalyst to form aryl amines. The catalyst used in this reaction is of the form PdL2, where, L stands for ligand. The mechanism of this reaction includes oxidative addition and reductive elimination. AlCl3

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Answer 4

Question

Chapter 23, Problem 23.37P

Interpretation Introduction

(a)

Interpretation:

The compound, N-(sec-butyl)-N-ethylaniline from chlorobenzene is to be synthesized.

Concept introduction:

Butchwald-Hatwig amination is the reaction in which aryl halides are directly aminated in the presence of a base and a catalyst to form aryl amines. The palladium catalyst is used in this reaction is PdL2, where, L stands for ligand. The mechanism of this reaction includes oxidative addition and reductive elimination.

Interpretation Introduction

(b)

Interpretation:

The compound, 4-(4-tert-butylphenyl)morpholine from phenol is to be synthesized.

Concept introduction:

Butchwald-Hatwig amination is the reaction in which aryl halides are directly aminated in the presence of a base and a catalyst to form aryl amines. The catalyst used in this reaction is of the form PdL2, where, L stands for ligand. The mechanism of this reaction includes oxidative addition and reductive elimination.

Interpretation Introduction

(c)

Interpretation:

The compound, phenyl(4-(phenylamino)phenyl)methane from chlorobenzene is to be synthesized.

Concept introduction:

Butchwald-Hatwig amination is the reaction in which aryl halides are directly aminated in the presence of a base and a catalyst to form aryl amines. The catalyst used in this reaction is of the form PdL2, where, L stands for ligand. The mechanism of this reaction includes oxidative addition and reductive elimination. AlCl3

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Answer 5

Chapter 23, Problem 23.37P

Interpretation Introduction

(a)

Interpretation:

The compound, N-(sec-butyl)-N-ethylaniline from chlorobenzene is to be synthesized.

Concept introduction:

Butchwald-Hatwig amination is the reaction in which aryl halides are directly aminated in the presence of a base and a catalyst to form aryl amines. The palladium catalyst is used in this reaction is PdL2, where, L stands for ligand. The mechanism of this reaction includes oxidative addition and reductive elimination.

Interpretation Introduction

(b)

Interpretation:

The compound, 4-(4-tert-butylphenyl)morpholine from phenol is to be synthesized.

Concept introduction:

Butchwald-Hatwig amination is the reaction in which aryl halides are directly aminated in the presence of a base and a catalyst to form aryl amines. The catalyst used in this reaction is of the form PdL2, where, L stands for ligand. The mechanism of this reaction includes oxidative addition and reductive elimination.

Interpretation Introduction

(c)

Interpretation:

The compound, phenyl(4-(phenylamino)phenyl)methane from chlorobenzene is to be synthesized.

Concept introduction:

Butchwald-Hatwig amination is the reaction in which aryl halides are directly aminated in the presence of a base and a catalyst to form aryl amines. The catalyst used in this reaction is of the form PdL2, where, L stands for ligand. The mechanism of this reaction includes oxidative addition and reductive elimination. AlCl3

Answer 6

Chapter 23, Problem 23.37P

Interpretation Introduction

(a)

Interpretation:

The compound, N-(sec-butyl)-N-ethylaniline from chlorobenzene is to be synthesized.

Concept introduction:

Butchwald-Hatwig amination is the reaction in which aryl halides are directly aminated in the presence of a base and a catalyst to form aryl amines. The palladium catalyst is used in this reaction is PdL2, where, L stands for ligand. The mechanism of this reaction includes oxidative addition and reductive elimination.

Answer 7

Chapter 23, Problem 23.37P

Interpretation Introduction

(a)

Interpretation:

The compound, N-(sec-butyl)-N-ethylaniline from chlorobenzene is to be synthesized.

Concept introduction:

Butchwald-Hatwig amination is the reaction in which aryl halides are directly aminated in the presence of a base and a catalyst to form aryl amines. The palladium catalyst is used in this reaction is PdL2, where, L stands for ligand. The mechanism of this reaction includes oxidative addition and reductive elimination.

Answer 8

Interpretation Introduction

(b)

Interpretation:

The compound, 4-(4-tert-butylphenyl)morpholine from phenol is to be synthesized.

Concept introduction:

Butchwald-Hatwig amination is the reaction in which aryl halides are directly aminated in the presence of a base and a catalyst to form aryl amines. The catalyst used in this reaction is of the form PdL2, where, L stands for ligand. The mechanism of this reaction includes oxidative addition and reductive elimination.

Answer 9

Interpretation Introduction

(b)

Interpretation:

The compound, 4-(4-tert-butylphenyl)morpholine from phenol is to be synthesized.

Concept introduction:

Butchwald-Hatwig amination is the reaction in which aryl halides are directly aminated in the presence of a base and a catalyst to form aryl amines. The catalyst used in this reaction is of the form PdL2, where, L stands for ligand. The mechanism of this reaction includes oxidative addition and reductive elimination.

Answer 10

Interpretation Introduction

(c)

Interpretation:

The compound, phenyl(4-(phenylamino)phenyl)methane from chlorobenzene is to be synthesized.

Concept introduction:

Butchwald-Hatwig amination is the reaction in which aryl halides are directly aminated in the presence of a base and a catalyst to form aryl amines. The catalyst used in this reaction is of the form PdL2, where, L stands for ligand. The mechanism of this reaction includes oxidative addition and reductive elimination. AlCl3

Answer 11

Interpretation Introduction

(c)

Interpretation:

The compound, phenyl(4-(phenylamino)phenyl)methane from chlorobenzene is to be synthesized.

Concept introduction:

Butchwald-Hatwig amination is the reaction in which aryl halides are directly aminated in the presence of a base and a catalyst to form aryl amines. The catalyst used in this reaction is of the form PdL2, where, L stands for ligand. The mechanism of this reaction includes oxidative addition and reductive elimination. AlCl3

Answer 12

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Answer 13

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Answer 14

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Answer 15

Ch. 23 - Prob. 23.1P Ch. 23 - Prob. 23.2P Ch. 23 - Prob. 23.3P Ch. 23 - Prob. 23.4P Ch. 23 - Prob. 23.5P Ch. 23 - Prob. 23.6P Ch. 23 - Prob. 23.7P Ch. 23 - Prob. 23.8P Ch. 23 - Prob. 23.9P Ch. 23 - Prob. 23.10P

Solution Summary: The author explains that chlorobenzene undergoes Buchwald-Hartwig amination by reacting with sec -butylamine to form aryl amines.

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Chapter 23 Solutions