A reasonable mechanism for HMG-CoA synthase reaction should be written. Concept Introduction: Acetyl CoA produced by ß oxidation of fatty acids undergoes further oxidation in the TCA cycle. Some of this acetyl CoA is converted into three metabolites; acetone, acetoacetate and ß hydroxybutyrate. Process of formation of these metabolites is known as ketogenesis. Although ß hydroxybutyrate does not have a ketone functional group , those three groups are known as ketone bodies.

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9) Below, there is a representation of an SDS-PAGE gel. Assuming the samples in the MW standard have masses of: 66 kDa, 45 kDa, 36 kDa, 29 kDa, 24 kDa, 20.1 kDa, and 14.2 kDa, a) Figure 4: indicate where each of the measurements were taken and label as in II.6. figure 2 above. b) As in II.7. Table 1 above create Table 2 using the data below. Determine the r.f. values for the MW standards, plot the relative mobility versus the log of the mass for the standards, and use the best fit straight line to determine the molecular weights of the proteins in the whey, peak 1, and peak 2 lanes. (5 pts—this will be scaled up appropriately if your gel did not develop properly) dye MW Whey Peak 1 Peak 2

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Chapter 23, Problem 13P

Interpretation Introduction

Interpretation:

A reasonable mechanism for HMG-CoA synthase reaction should be written.

Concept Introduction:

Acetyl CoA produced by ß oxidation of fatty acids undergoes further oxidation in the TCA cycle. Some of this acetyl CoA is converted into three metabolites; acetone, acetoacetate and ß hydroxybutyrate. Process of formation of these metabolites is known as ketogenesis. Although ß hydroxybutyrate does not have a ketone functional group, those three groups are known as ketone bodies.

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