What would happen if a thymocyte that failed the negative selection test was not destroyed and instead entered the blood to circulate as a T-lymphocyte. Concept introduction: The T lymphocytes initiate cell-mediated immunity in which a number of immune cells including phagocytes, helper T cells, cytotoxic T cells, and other immune cells get activated and together fight against the invading pathogen. T-lymphocytes that survive both positive and negative selections can bind a major histocompatibility complex (MHC) molecule and recognize the foreign antigen.

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Chapter 22.5, Problem 19WDL

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To determine: What would happen if a thymocyte that failed the negative selection test was not destroyed and instead entered the blood to circulate as a T-lymphocyte.

Concept introduction: The T lymphocytes initiate cell-mediated immunity in which a number of immune cells including phagocytes, helper T cells, cytotoxic T cells, and other immune cells get activated and together fight against the invading pathogen. T-lymphocytes that survive both positive and negative selections can bind a major histocompatibility complex (MHC) molecule and recognize the foreign antigen.

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