Whether GLUT transporters are active or passive transporters Introduction: The primary source for the production of ATP is glucose. It is absorbed by the walls of intestine to the bloodstream and then reaches the liver. The metabolism of 30% ingested glucose occurs in liver.

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Chapter 22.4, Problem 7CC

Summary Introduction

To determine: Whether GLUT transporters are active or passive transporters

Introduction: The primary source for the production of ATP is glucose. It is absorbed by the walls of intestine to the bloodstream and then reaches the liver. The metabolism of 30% ingested glucose occurs in liver.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…

The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?

Answer 2

Question

Chapter 22.4, Problem 7CC

Summary Introduction

To determine: Whether GLUT transporters are active or passive transporters

Introduction: The primary source for the production of ATP is glucose. It is absorbed by the walls of intestine to the bloodstream and then reaches the liver. The metabolism of 30% ingested glucose occurs in liver.

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Answer 3

Question

Chapter 22.4, Problem 7CC

Summary Introduction

To determine: Whether GLUT transporters are active or passive transporters

Introduction: The primary source for the production of ATP is glucose. It is absorbed by the walls of intestine to the bloodstream and then reaches the liver. The metabolism of 30% ingested glucose occurs in liver.

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Answer 4

Question

Chapter 22.4, Problem 7CC

Summary Introduction

To determine: Whether GLUT transporters are active or passive transporters

Introduction: The primary source for the production of ATP is glucose. It is absorbed by the walls of intestine to the bloodstream and then reaches the liver. The metabolism of 30% ingested glucose occurs in liver.

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Answer 5

Chapter 22.4, Problem 7CC

Summary Introduction

To determine: Whether GLUT transporters are active or passive transporters

Introduction: The primary source for the production of ATP is glucose. It is absorbed by the walls of intestine to the bloodstream and then reaches the liver. The metabolism of 30% ingested glucose occurs in liver.

Answer 6

Chapter 22.4, Problem 7CC

Summary Introduction

To determine: Whether GLUT transporters are active or passive transporters

Introduction: The primary source for the production of ATP is glucose. It is absorbed by the walls of intestine to the bloodstream and then reaches the liver. The metabolism of 30% ingested glucose occurs in liver.

Answer 7

Chapter 22.4, Problem 7CC

Summary Introduction

To determine: Whether GLUT transporters are active or passive transporters

Introduction: The primary source for the production of ATP is glucose. It is absorbed by the walls of intestine to the bloodstream and then reaches the liver. The metabolism of 30% ingested glucose occurs in liver.

Answer 8

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Answer 11

Ch. 22.1 - Explain the roles of the satiety and feeding...Ch. 22.1 - Name the four layers of the GI tract wall,...Ch. 22.2 - Prob. 3CC Ch. 22.2 - Prob. 4CC Ch. 22.2 - Prob. 5CC Ch. 22.2 - Prob. 6CC Ch. 22.4 - Prob. 7CC Ch. 22.4 - Prob. 8CC Ch. 22.4 - Use your understanding of digestive physiology to...Ch. 22.5 - Prob. 10CC

Whether GLUT transporters are active or passive transporters Introduction: The primary source for the production of ATP is glucose. It is absorbed by the walls of intestine to the bloodstream and then reaches the liver. The metabolism of 30% ingested glucose occurs in liver.

Solution Summary: The author explains that the primary source for the production of ATP is glucose. Glucose moves from the intestinal fluid into the cells by membrane GLUT transporters.

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To determine: Whether GLUT transporters are active or passive transporters

Introduction: The primary source for the production of ATP is glucose. It is absorbed by the walls of intestine to the bloodstream and then reaches the liver. The metabolism of 30% ingested glucose occurs in liver.

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Chapter 22 Solutions

Whether GLUT transporters are active or passive transporters Introduction: The primary source for the production of ATP is glucose. It is absorbed by the walls of intestine to the bloodstream and then reaches the liver. The metabolism of 30% ingested glucose occurs in liver.

Solution Summary: The author explains that the primary source for the production of ATP is glucose. Glucose moves from the intestinal fluid into the cells by membrane GLUT transporters.

Concept explainers

Videos

To determine: Whether GLUT transporters are active or passive transporters Introduction: The primary source for the production of ATP is glucose. It is absorbed by the walls of intestine to the bloodstream and then reaches the liver. The metabolism of 30% ingested glucose occurs in liver.

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Chapter 22 Solutions

To determine: Whether GLUT transporters are active or passive transporters

Introduction: The primary source for the production of ATP is glucose. It is absorbed by the walls of intestine to the bloodstream and then reaches the liver. The metabolism of 30% ingested glucose occurs in liver.