
(a)
Interpretation:
The effects of increasing the concentration of tissue fructose-1,6-bisphosphate on the rates of gluconeogenesis and glycogen
Concept Introduction:
Most of the reactions in Glycolysis and Gluconeogenesis reactions are taken place in the cytosol. Therefore, unless there is a metabolic regulation, glycolytic degradation of glucose and gluconeogenic synthesis of glucose will occur simultaneously without a benefit to the cell with huge consumption of ATP. This scenario is controlled by a reciprocal control system which inhibits glycolysis when gluconeogenesis is active and vice versa.
Glucose produced by glycogen metabolism is also an energy source for muscle contraction. Regulation of glycogen metabolism is also a reciprocal control of the two-enzyme glycogen phosphorylase and glycogen synthase. Regulation is achieved via both allosteric regulation and covalent modification.
(b)
Interpretation:
The effects of increasing the concentration of blood glucose on the rates of gluconeogenesis and glycogen metabolism should be explained.
Concept Introduction:
Most of the reactions in Glycolysis and Gluconeogenesis reactions are taken place in the cytosol. Therefore, unless there is a metabolic regulation, glycolytic degradation of glucose and gluconeogenic synthesis of glucose will occur simultaneously without a benefit to the cell with huge consumption of ATP. This scenario is controlled by a reciprocal control system which inhibits glycolysis when gluconeogenesis is active and vice versa.
Glucose produced by glycogen metabolism is also an energy source for muscle contraction. Regulation of glycogen metabolism is also a reciprocal control of the two enzyme glycogen phosphorylase and glycogen synthase. Regulation is achieved via both allosteric regulation and covalent modification.
(c)
To Explain:
The effects of increasing the concentration of blood insulin on the rates of gluconeogenesis and glycogen metabolism should be explained.
Introduction:
Most of the reactions in Glycolysis and Gluconeogenesis reactions are taken place in the cytosol. Therefore, unless there is a metabolic regulation, glycolytic degradation of glucose and gluconeogenic synthesis of glucose will occur simultaneously without a benefit to the cell with huge consumption of ATP. This scenario is controlled by a reciprocal control system which inhibits glycolysis when gluconeogenesis is active and vice versa.
Glucose produced by glycogen metabolism is also an energy source for muscle contraction. Regulation of glycogen metabolism is also a reciprocal control of the two enzyme glycogen phosphorylase and glycogen synthase. Regulation is achieved via both allosteric regulation and covalent modification.
(d)
To Explain:
The effects of increasing the amount of blood glucagon on the rates of gluconeogenesis and glycogen metabolism should be explained.
Introduction:
Most of the reactions in Glycolysis and Gluconeogenesis reactions are taken place in the cytosol. Therefore, unless there is a metabolic regulation, glycolytic degradation of glucose and gluconeogenic synthesis of glucose will occur simultaneously without a benefit to the cell with huge consumption of ATP. This scenario is controlled by a reciprocal control system which inhibits glycolysis when gluconeogenesis is active and vice versa.
Glucose produced by glycogen metabolism is also an energy source for muscle contraction. Regulation of glycogen metabolism is also a reciprocal control of the two enzyme glycogen phosphorylase and glycogen synthase. Regulation is achieved via both allosteric regulation and covalent modification.
(e)
Interpretation:
The effects of decreasing levels of tissue ATP on the rates of gluconeogenesis and glycogen metabolism should be explained.
Concept Introduction:
Most of the reactions in Glycolysis and Gluconeogenesis reactions are taken place in the cytosol. Therefore, unless there is a metabolic regulation, glycolytic degradation of glucose and gluconeogenic synthesis of glucose will occur simultaneously without a benefit to the cell with huge consumption of ATP. This scenario is controlled by a reciprocal control system which inhibits glycolysis when gluconeogenesis is active and vice versa.
Glucose produced by glycogen metabolism is also an energy source for muscle contraction. Regulation of glycogen metabolism is also a reciprocal control of the two enzyme glycogen phosphorylase and glycogen synthase. Regulation is achieved via both allosteric regulation and covalent modification.
(f)
Interpretation:
The effects of increasing the concentration of tissue AMP on the rates of gluconeogenesis and glycogen metabolism should be explained.
Concept Introduction:
Most of the reactions in Glycolysis and Gluconeogenesis reactions are taken place in the cytosol. Therefore, unless there is a metabolic regulation, glycolytic degradation of glucose and gluconeogenic synthesis of glucose will occur simultaneously without a benefit to the cell with huge consumption of ATP. This scenario is controlled by a reciprocal control system which inhibits glycolysis when gluconeogenesis is active and vice versa.
Glucose produced by glycogen metabolism is also an energy source for muscle contraction. Regulation of glycogen metabolism is also a reciprocal control of the two enzyme glycogen phosphorylase and glycogen synthase. Regulation is achieved via both allosteric regulation and covalent modification.
(g)
Interpretation:
The effects of decreasing the concentration of fructose-6-phosphate on the rates of gluconeogenesis and glycogen metabolism should be explained.
Concept Introduction:
Most of the reactions in Glycolysis and Gluconeogenesis reactions are taken place in the cytosol. Therefore, unless there is a metabolic regulation, glycolytic degradation of glucose and gluconeogenic synthesis of glucose will occur simultaneously without a benefit to the cell with huge consumption of ATP. This scenario is controlled by a reciprocal control system which inhibits glycolysis when gluconeogenesis is active and vice versa.
Glucose produced by glycogen metabolism is also an energy source for muscle contraction. Regulation of glycogen metabolism is also a reciprocal control of the two enzyme glycogen phosphorylase and glycogen synthase. Regulation is achieved via both allosteric regulation and covalent modification.

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Chapter 22 Solutions
EBK BIOCHEMISTRY
- A culture of kidneys cells contains all intermediates of the citric acid cycle. It is treated with an irreversible inhibitor of malate dehydrogenase, and then infused withglucose. Fill in the following list to account for the number of energy molecules that are formed from that one molecule of glucose in this situation. (NTP = nucleotidetriphosphate, e.g., ATP or GTP)Net number of NTP:Net number of NADH:Net number of FADH2:arrow_forward16. Which one of the compounds below is the final product of the reaction sequence shown here? OH A B NaOH Zn/Hg aldol condensation heat aq. HCI acetone C 0 D Earrow_forward2. Which one of the following alkenes undergoes the least exothermic hydrogenation upon treatment with H₂/Pd? A B C D Earrow_forward
- 6. What is the IUPAC name of the following compound? A) (Z)-3,5,6-trimethyl-3,5-heptadiene B) (E)-2,3,5-trimethyl-1,4-heptadiene C) (E)-5-ethyl-2,3-dimethyl-1,5-hexadiene D) (Z)-5-ethyl-2,3-dimethyl-1,5-hexadiene E) (Z)-2,3,5-trimethyl-1,4-heptadienearrow_forwardConsider the reaction shown. CH2OH Ex. CH2 -OH CH2- Dihydroxyacetone phosphate glyceraldehyde 3-phosphate The standard free-energy change (AG) for this reaction is 7.53 kJ mol-¹. Calculate the free-energy change (AG) for this reaction at 298 K when [dihydroxyacetone phosphate] = 0.100 M and [glyceraldehyde 3-phosphate] = 0.00300 M. AG= kJ mol-1arrow_forwardIf the pH of gastric juice is 1.6, what is the amount of energy (AG) required for the transport of hydrogen ions from a cell (internal pH of 7.4) into the stomach lumen? Assume that the membrane potential across this membrane is -70.0 mV and the temperature is 37 °C. AG= kJ mol-1arrow_forward
- Consider the fatty acid structure shown. Which of the designations are accurate for this fatty acid? 17:2 (48.11) 18:2(A9.12) cis, cis-A8, A¹¹-octadecadienoate w-6 fatty acid 18:2(A6,9)arrow_forwardClassify the monosaccharides. H-C-OH H. H-C-OH H-C-OH CH₂OH H-C-OH H-C-OH H-C-OH CH₂OH CH₂OH CH₂OH CH₂OH D-erythrose D-ribose D-glyceraldehyde Dihydroxyacetone CH₂OH CH₂OH C=O Answer Bank CH₂OH C=0 HO C-H C=O H-C-OH H-C-OH pentose hexose tetrose H-C-OH H-C-OH H-C-OH aldose triose ketose CH₂OH CH₂OH CH₂OH D-erythrulose D-ribulose D-fructosearrow_forwardFatty acids are carboxylic acids with long hydrophobic tails. Draw the line-bond structure of cis-A9-hexadecenoate. Clearly show the cis-trans stereochemistry.arrow_forward
- The formation of acetyl-CoA from acetate is an ATP-driven reaction: Acetate + ATP + COA Acetyl CoA+AMP+ PP Calculate AG for this reaction given that the AG for the hydrolysis of acetyl CoA to acetate and CoA is -31.4 kJ mol-1 (-7.5 kcal mol-¹) and that the AG for hydrolysis of ATP to AMP and PP; is -45.6 kJ mol-1 (-10.9 kcal mol-¹). AG reaction kJ mol-1 The PP, formed in the preceding reaction is rapidly hydrolyzed in vivo because of the ubiquity of inorganic pyrophosphatase. The AG for the hydrolysis of pyrophosphate (PP.) is -19.2 KJ mol-¹ (-4.665 kcal mol-¹). Calculate the AG° for the overall reaction, including pyrophosphate hydrolysis. AGO reaction with PP, hydrolysis = What effect does the presence of pyrophosphatase have on the formation of acetyl CoA? It does not affect the overall reaction. It makes the overall reaction even more endergonic. It brings the overall reaction closer to equilibrium. It makes the overall reaction even more exergonic. kJ mol-1arrow_forwardConsider the Haworth projections of ẞ-L-galactose and ẞ-L-glucose shown here. OH CH₂OH OH CH₂OH OH OH OH ОН OH он B-L-galactose B-L-glucose Which terms describe the relationship between these two sugars? epimers enantiomers anomers diastereomersarrow_forwardClassify each characteristic as describing anabolism or catabolism. Anabolism Answer Bank Catabolism transforms fuels into cellular energy, such as ATP or ion gradients uses NADPH as the electron carrier synthesizes macromolecules requires energy inputs, such as ATP uses NAD+ as the electron carrier breaks down macromoleculesarrow_forward
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