Chapter 22, Problem 58P

Interpretation Introduction

Interpretation: The function of ${\text{Mn}}^{2+}$ in the activity of the protein kinase enzyme is to be explained.

Concept introduction:

Enzymes can be simple (comprising of only amino acids) or conjugated (having a cofactor along with amino acids). A holoenzyme is formed with a protein component (the apoenzyme) and a cofactor (a non-protein group involved in enzyme activity). These cofactors can be associated with amino acids either covalently or non-covalently (called prosthetic group). Some of them are the metal ions (such as ${\text{Mn}}^{2+}$ , ${\text{Cu}}^{2+}$ , and ${\text{Mg}}^{2+}$ ) while others are complex organic compounds (called coenzymes).