Chapter 22, Problem 38P

Interpretation Introduction

Interpretation:

How would isozymes migrate if m subunit has lower pI than L subunit of PFK is to be determined.

Concept Introduction:

Phosphofructokinase (PFK) occur in two types of subunit: m and L. m is for muscle and L is for the liver. These two subunits form a tetramer and are present in five different combinations which are: ${\text{M}}_{\text{4}}{\text{, L}}_{\text{4}}{\text{, ML}}_{\text{3}}{\text{, M}}_{\text{2}}{\text{L}}_{\text{2}}$ and ${\text{M}}_{\text{3}}\text{L}$.