Fundamentals of Biochemistry: Life at the Molecular Level
Fundamentals of Biochemistry: Life at the Molecular Level
5th Edition
ISBN: 9781118918401
Author: Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher: WILEY
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Chapter 22, Problem 26E
Summary Introduction

To explain: The advantage for some tumors to stop expressing the genes for glucose-6-phosphatase, phosphoenolpyruvate carboxykinase, and fructose bisphosphatase.

Concept introduction: Glucose-6-phosphate, phosphoenolpyruvate carboxykinase, and fructose bisphosphatase are the three important enzymes in the gluconeogenesis pathway. Glucose-6-phosphatase hydrolyzes glucose-6-phosphate that results in the creation of phosphate group and free glucose. Phosphoenolpyruvate carboxykinase converts the oxaloacetate into phosphoenolpyruvate and carbon dioxide. Fructose bisphosphatase converts fructose-1,6-bisphosphate to fructose 6-phosphate.

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