Fundamentals of Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134396026
Author: Frederic H. Martini, Judi L. Nath, Edwin F. Bartholomew
Publisher: PEARSON
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Chapter 22, Problem 21RQ
How does a cytotoxic T cell destroy another cell displaying antigens bound to class I MHC proteins?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 22 Solutions
Fundamentals of Anatomy & Physiology (11th Edition)
Ch. 22 - Define pathogen.Ch. 22 - Prob. 2CPCh. 22 - How would blockage of the thoracic duct affect...Ch. 22 - Prob. 4CPCh. 22 - Prob. 5CPCh. 22 - Prob. 6CPCh. 22 - Prob. 7CPCh. 22 - Prob. 8CPCh. 22 - Prob. 9CPCh. 22 - What effects do pyrogens have in the body?
Ch. 22 - Explain the difference between cell-mediated...Ch. 22 - Prob. 12CPCh. 22 - Prob. 13CPCh. 22 - Prob. 14CPCh. 22 - How can the presence of an abnormal peptide in the...Ch. 22 - A decrease in the number of cytotoxic T cells...Ch. 22 - How would a lack of helper T cells affect the...Ch. 22 - Prob. 18CPCh. 22 - Prob. 19CPCh. 22 - Prob. 20CPCh. 22 - Which would be more negatively affectedthe primary...Ch. 22 - Which kind of immunity protects a developing...Ch. 22 - How does increased stress reduce the effectiveness...Ch. 22 - Prob. 24CPCh. 22 - Prob. 25CPCh. 22 - What may account for the increased incidence of...Ch. 22 - Prob. 27CPCh. 22 - Prob. 28CPCh. 22 - LEVEL 1 Reviewing Facts and Terms 1. Identify the...Ch. 22 - Prob. 2RQCh. 22 - Anatomically, lymphatic vessels resemble (a)...Ch. 22 - Prob. 4RQCh. 22 - Prob. 5RQCh. 22 - Prob. 6RQCh. 22 - Phagocytes move through capillary walls by...Ch. 22 - Prob. 8RQCh. 22 - Prob. 9RQCh. 22 - Prob. 10RQCh. 22 - CD4 markers are associated with (a) cytotoxic T...Ch. 22 - Prob. 12RQCh. 22 - Prob. 13RQCh. 22 - What are the three classes of lymphocytes, and...Ch. 22 - What seven defenses present at birth provide the...Ch. 22 - Compared with innate defenses adaptive defenses...Ch. 22 - Prob. 17RQCh. 22 - A decrease in which population of lymphocytes...Ch. 22 - Skin tests are used to determine if a person (a)...Ch. 22 - Compare and contrast the effects of complement...Ch. 22 - How does a cytotoxic T cell destroy another cell...Ch. 22 - How does the formation of an antigen-antibody...Ch. 22 - Give one example of each type of immunity: innate...Ch. 22 - Prob. 24RQCh. 22 - An investigator at a crime scene discovers some...Ch. 22 - Ted finds out that he has been exposed to measles....Ch. 22 - While walking along the street, you and your...Ch. 22 - Paulas grandfather is diagnosed as having lung...Ch. 22 - Willy is allergic to ragweed pollen and tells you...Ch. 22 - Prob. 1CCCh. 22 - Does baby Ruthie still need her chickenpox vaccine...
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- List substitutions in your diet you could make to improve it based on what you know now about a balanced diet. For instance, if you like to drink soda, you might substitute skim milk or water for some of the soft drinks you consumed. List the item you wish to replace with the new item and what you hope to accomplish with that substitution. Be sure to choose foods you know that you'd enjoy and you consider more "healthful." If you feel your diet is already balanced, describe how you accomplish your balanced intake and when you began eating this way.arrow_forwardWhich single food item contained you ate for the 3 days with the most sodium?arrow_forwardSelect a diet and choose one site that provides credible information. Explain why the source itself and/or the information on the site is credible. This should be a report. This site should be different from U.S News and World Report. For full credit, you must include the following information and elaborate in detail: The diet name The main components of the diet The credible website name and link What makes the credible website credible?arrow_forward
- Select a diet and give a summary of the main components. Do a web search of the diet and choose one link that provides misinformation. Explain why the site itself and/or the information on the site is not credible. This should be a report. This site should be different from U.S News and World Report. For full credit, you must include the following information and elaborate in detail: The diet name The main components of the diet The misinformation website and link What misinformation is being provided in the other website and how did you determine it was not credible?arrow_forward1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.arrow_forward2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…arrow_forward
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