Principles of Anatomy and Physiology
Principles of Anatomy and Physiology
15th Edition
ISBN: 9781119329398
Author: Gerard J Tortora, Bryan Derrickson
Publisher: John Wiley & Sons Inc
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Chapter 22, Problem 20CP
Summary Introduction

To review:

The use of immunological surveillance.

Introduction:

Immunological surveillance is a monitoring process of the immune system to detect and destroy virally infected and neoplastically transformed cells in the body. The tumor antigens, that is, the novel cell surface components are displayed once a normal cell converts into the cancerous cell. These components are generally not displayed on the surface of normal cells.

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Noggin mutation: The mouse, one of the phenotypic consequences of Noggin mutationis mispatterning of the spinal cord, in the posterior region of the mouse embryo, suchthat in the hindlimb region the more ventral fates are lost, and the dorsal Pax3 domain isexpanded. (this experiment is not in the lectures).a. Hypothesis for why: What would be your hypothesis for why the ventral fatesare lost and dorsal fates expanded? Include in your answer the words notochord,BMP, SHH and either (or both of) surface ectoderm or lateral plate mesoderm
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