GENETICS:ANALYSIS+PRIN.(LL)-W/ACCESS
GENETICS:ANALYSIS+PRIN.(LL)-W/ACCESS
6th Edition
ISBN: 9781260239775
Author: BROOKER
Publisher: MCG
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Chapter 22, Problem 1QSDC
Summary Introduction

To review:

The advantages and disadvantages of gene therapy. The top three diseasesthatneed researchfunding.

Introduction:

Gene therapy is a technique that is to prevent or cure a wide range of diseases by correcting the defective gene which is responsible for causing the disease. It is divided into two types. They are;somatic cell gene therapy which involves the replacement of defective genes in bone marrow, blood cell, skin cells, and germ cells, andgermline gene therapy whichinvolves the alteration of defective genes in the egg and sperm.

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a. What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent.  b. What will happen to elimination of the drug in the previous question if the system is saturated? explain and show any math involved
If you wanted to reduce the difference between peak and trough levels that occur with repeated administration of a drug, how would you adjust the dose and dose interval without changing the plateau concentration (plateau is the average of peak and trough levels)? Select your answers for both dose and interval. Hint: It may be helpful to think about this problem using an example such as food. How would you eat if you wanted to maintain very steady hunger/satiety levels without changing your total caloric intake? Options: A. Dose; Increase dose     B. Dose; Decrease dose     C. Dose; Do not change dose     D. Interval; Increase the interval between doses (give the drug less frequently)    E. Interval; Decrease the interval between doses (give the drug more frequently)     F. Interval; Do not change the interval
What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent. Show the math

Chapter 22 Solutions

GENETICS:ANALYSIS+PRIN.(LL)-W/ACCESS

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