EP PRINCIPLES OF HUM.PHYS.-MOD.MAST.A+P
6th Edition
ISBN: 9780134407166
Author: STANFIELD
Publisher: PEARSON CO
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Chapter 22, Problem 13E
In the absence of testosterone and MIS, the Müllerian ducts (persistldegenerate) n the embryo, and female structures eventually develop.
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Biopharmaceutics and Pharmacokinetics:Two-Compartment Model Instant Absorption Questions
SHOW ALL WORK, including equation used, variables used and each step to your solution, report your regression lines and axes names (with units if appropriate) :Calculate a-q
a) B1,
b) B2,
c) hybrid rate constant (1)
d) hybrid rate constant (2)
e) t1/2,dist
f) t1/2,elim
g) k10
h) k12
i) k21
j) initial concentration (C0)
k) central compartment volume (V1)
l) steady-state volume (Vss)
m) clearance (CL) AUC (0→10 min) using trapezoidal rule
n) AUC (20→30 min) using trapezoidal rule
o) AUCtail (AUC360→∞)
p) total AUC (using short cut method)
q) volume from AUC (VAUC)
Glitazones reduce insulin resistance by binding to a transcription factor in adipocytes, thereby reducing thesecretion of fatty acids. Glitazones are taken orally (in pill form). Using pharmacokinetic modeling, deriveequations to describe how the concentration of glitazones varies in the plasma as a function of time. Yourequations should be of the form: dCglitazone /dt = something, or dMglitazone /dt = something. Your model shouldinclude three compartments: the gut, the plasma, and the fatty tissues. Make sure to include a diagram thatillustrates your thinking, state all assumptions, and define your variables. Do not solve the equations.
Case Study—Ella
Review the case study and then answer Parts A through F.
Ella has a family history of diabetes. She wants to follow a healthful eating pattern that can lower her risk for developing this condition. Her dietitian recommends a goal of 450 to 600 kcal per meal and advises Ella to follow the Acceptable Macronutrient Distribution Range (AMDR) for carbohydrates and the Dietary Guidelines for Americans 2015-2020, which recommend limiting added sugar. She also recommends that Ella choose whole grains rather than processed grains. Ella decides to pack a lunch to take to work every day. This morning she’s making a sandwich for her lunch.
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_____…
Chapter 22 Solutions
EP PRINCIPLES OF HUM.PHYS.-MOD.MAST.A+P
Ch. 22.1 - Why are men more likely to demonstrate X-linked...Ch. 22.1 - Prob. 2CTQCh. 22.1 - Prob. 3CTQCh. 22.1 - Prob. 22.1.1QCCh. 22.1 - Prob. 22.1.2QCCh. 22.2 - Prob. 1CTQCh. 22.2 - Prob. 2CTQCh. 22.2 - Prob. 3CTQCh. 22.2 - Prob. 22.2.1QCCh. 22.2 - Prob. 22.2.2QC
Ch. 22.3 - How does oogenesis differ from spermatogeriesis...Ch. 22.3 - When do meiosis I and meiosis II occur in...Ch. 22.3 - Describe the different types of functional ovarian...Ch. 22.3 - Why are endometriomas potentially severe? Describe...Ch. 22.3 - Prob. 3CTQCh. 22.3 - Prob. 22.4.1QCCh. 22.3 - Prob. 22.4.2QCCh. 22.4 - Prob. 22.5.1QCCh. 22.4 - Prob. 22.5.2QCCh. 22.4 - Prob. 22.5.3QCCh. 22.4 - Prob. 22.5.4QCCh. 22.5 - For each of the following descriptive phrases,...Ch. 22 - Prob. 1ECh. 22 - In the embryo, which of the following effects s...Ch. 22 - The testes are housed in a structure called...Ch. 22 - Prob. 4ECh. 22 - Prob. 5ECh. 22 - Prob. 6ECh. 22 - Prob. 7ECh. 22 - Prob. 8ECh. 22 - In the uterine cycle, which phase immediately...Ch. 22 - The placenta not only serves as an organ of...Ch. 22 - In meiosis I, maternal and paternal chromosomes...Ch. 22 - The srY gene codes for (testosterone...Ch. 22 - In the absence of testosterone and MIS, the...Ch. 22 - FSH and LH are classified as (sex...Ch. 22 - Prob. 15ECh. 22 - Prob. 16ECh. 22 - Spermatogenesis is stimulated by testosterone and...Ch. 22 - The head of a sperm contains chromosomes and a(n),...Ch. 22 - Prob. 19ECh. 22 - Prob. 20ECh. 22 - Prob. 21ECh. 22 - Prob. 22ECh. 22 - Prob. 23ECh. 22 - Prob. 24ECh. 22 - Prob. 25ECh. 22 - Prob. 26ECh. 22 - Prob. 27ECh. 22 - Prob. 28ECh. 22 - Prob. 29ECh. 22 - Degeneration of the corpus luteum causes hormonal...Ch. 22 - Before implantation, the morula develops into...Ch. 22 - Secretory-phase utenne conditions are promoted by...Ch. 22 - Prob. 33ECh. 22 - Prob. 34ECh. 22 - Prob. 35ECh. 22 - Prob. 36ECh. 22 - Prob. 37ECh. 22 - Prob. 38ECh. 22 - Prob. 39ECh. 22 - Describe the processes that give rise to elevated...Ch. 22 - Prob. 41ECh. 22 - Prob. 42ECh. 22 - Some males are sterile because their sperm cannot...Ch. 22 - Prob. 44E
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