Chapter 22, Problem 101E

Interpretation Introduction

Interpretation: The effect on the structure of hemoglobin by the substitution of $\text{valine}$ in place of glutamic acid is to be explained.

Concept introduction: Hemoglobin is an oxygen carrying pigment made up of four $\text{heme}$ groups that surrounds the $\text{globin}$ group. $\text{Heme}$ Group contains an iron atom which is responsible for the red color to the molecule. In sickle-cell disease, hemoglobin S is found. It is a type of anemia in which oxygen is in short supply and all the red blood cells become sickle-shaped. Hence, it is known as sickle-cell anemia.

To determine: The effect on the structure of hemoglobin by the substitution of $\text{valine}$ in place of glutamic acid.