Chapter 21.7, Problem 8LTS

Interpretation Introduction

Interpretation:

Using 1-butanol as only carbon source the synthesis of given compound need to be proposed.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a $\beta$-keto ester or a $\beta$-diketone, respectively

• Deprotonation of $\alpha$ carbon to form ester enolate
• Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)
• Loss of alkoxide ion to reform carbonyl

Esterification is a process in which an carboxylic acid is treated with alcohol in presence of acid to form an ester.

Oxidation of primary alcohol using chromic acid leads to the formation of respective carboxylic acid.