To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation. Concept introduction: Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively Deprotonation of α carbon to form ester enolate Attach of enolate ion with the carbonyl of ester or ketone ( nucleophilic attack ) Loss of alkoxide ion to reform carbonyl Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation . LDA is used as a base in crossed claisen condensation. To identify : The identify the reagent used for the given compound synthesized via claisen condensation

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Answer 1

Question

Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 21.4, Problem 26CC

(a)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

(b)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

(c)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

(d)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

(e)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

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Answer 2

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Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 21.4, Problem 26CC

(a)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

(b)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

(c)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

(d)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

(e)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

Expert Solution & Answer

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Answer 3

Question

Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 21.4, Problem 26CC

(a)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

(b)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

(c)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

(d)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

(e)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

Expert Solution & Answer

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Check out a sample textbook solution

See solution

Answer 4

Question

Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 21.4, Problem 26CC

(a)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

(b)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

(c)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

(d)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

(e)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

Expert Solution & Answer

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Check out a sample textbook solution

See solution

Answer 5

Chapter 21.4, Problem 26CC

(a)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

(b)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

(c)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

(d)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

(e)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

Answer 6

Chapter 21.4, Problem 26CC

(a)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

Answer 7

Chapter 21.4, Problem 26CC

(a)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

Answer 8

(b)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

Answer 9

(b)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

Answer 10

(c)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

Answer 11

(c)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

Answer 12

(d)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

Answer 13

(d)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

Answer 14

(e)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

Answer 15

(e)

Interpretation Introduction

Interpretation:

To predict the reagent used for obtaining the given set of compounds synthesized by claisen condensation.

Concept introduction:

Claisen condensation is a process where a carbon-carbon bond is formed when reaction occurs between two esters or one ester and carbonyl compound in presence of a strong base to form a β -keto ester or a β -diketone, respectively

Deprotonation of α carbon to form ester enolate

Attach of enolate ion with the carbonyl of ester or ketone (nucleophilic attack)

Loss of alkoxide ion to reform carbonyl

Please note if the considered ester is of two different types then the reaction is known as crossed-claisen condensation. LDA is used as a base in crossed claisen condensation.

To identify : The identify the reagent used for the given compound synthesized via claisen condensation

Answer 16

Expert Solution & Answer

Answer 17

Expert Solution & Answer

Answer 18

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Check out a sample textbook solution

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Answer 19

Ch. 21.1 - Prob. 1CC Ch. 21.1 - Prob. 2CC Ch. 21.1 - Prob. 3CC Ch. 21.1 - Prob. 1LTS Ch. 21.1 - Prob. 4PTS Ch. 21.1 - APPLY the skill As with aldehydes and ketones, the...Ch. 21.1 - Draw the enolate ion that is formed when each of...Ch. 21.1 - Prob. 7CC Ch. 21.2 - Prob. 8CC Ch. 21.2 - Prob. 9CC

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Chapter 21 Solutions