SEELEY'S ANATOMY+PHYSIOLOGY
12th Edition
ISBN: 9781260172195
Author: VanPutte
Publisher: RENT MCG
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Chapter 21.4, Problem 25AYP
Summary Introduction
To analyze:
The areas that supplied by paired arteries branching from the abdominal aorta and the three unpaired arteries.
Introduction:
The nutrient and the gaseous exchange takes place in the blood and the vessels that form the circulatory system. The vessels are divided into arteries, veins, and capillaries.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 21 Solutions
SEELEY'S ANATOMY+PHYSIOLOGY
Ch. 21.1 - What is the difference between pulmonary and...Ch. 21.1 - Describe the five functions of the circulatory...Ch. 21.2 - Prob. 3AYPCh. 21.2 - Prob. 4AYPCh. 21.2 - Prob. 5AYPCh. 21.2 - Prob. 6AYPCh. 21.2 - Prob. 7AYPCh. 21.2 - Describe a capillary network. Where is the smooth...Ch. 21.2 - Prob. 9AYPCh. 21.2 - Prob. 10AYP
Ch. 21.2 - Prob. 11AYPCh. 21.2 - Prob. 12AYPCh. 21.2 - In which type of blood vessels are valves found?...Ch. 21.2 - Prob. 14AYPCh. 21.2 - Prob. 15AYPCh. 21.2 - Prob. 16AYPCh. 21.3 - Prob. 17AYPCh. 21.4 - Name the parts of the aorta.Ch. 21.4 - Name the arteries that branch from the ascending...Ch. 21.4 - Prob. 20AYPCh. 21.4 - Prob. 21AYPCh. 21.4 - Prob. 22AYPCh. 21.4 - Prob. 23AYPCh. 21.4 - Name the two types of branches arising from the...Ch. 21.4 - Prob. 25AYPCh. 21.4 - Prob. 26AYPCh. 21.4 - Prob. 27AYPCh. 21.5 - Prob. 28AYPCh. 21.5 - What veins collect blood from the heart muscle.Ch. 21.5 - Prob. 30AYPCh. 21.5 - Prob. 31AYPCh. 21.5 - Prob. 32AYPCh. 21.5 - Prob. 33AYPCh. 21.5 - Prob. 34AYPCh. 21.5 - Prob. 35AYPCh. 21.6 - Prob. 36AYPCh. 21.6 - Prob. 37AYPCh. 21.6 - Prob. 38AYPCh. 21.6 - Prob. 39AYPCh. 21.6 - Prob. 40AYPCh. 21.6 - Prob. 41AYPCh. 21.6 - Prob. 42AYPCh. 21.6 - Prob. 43AYPCh. 21.7 - Prob. 44AYPCh. 21.7 - Describe the total cross-sectional areas of the...Ch. 21.7 - Describe how the rate changes as blood flows...Ch. 21.7 - Prob. 47AYPCh. 21.7 - Prob. 48AYPCh. 21.7 - Prob. 49AYPCh. 21.7 - What is pulse pressure? How do stroke volume and...Ch. 21.7 - Prob. 51AYPCh. 21.7 - Prob. 52AYPCh. 21.7 - Prob. 53AYPCh. 21.7 - Prob. 54AYPCh. 21.7 - Prob. 55AYPCh. 21.7 - Prob. 56AYPCh. 21.7 - Prob. 57AYPCh. 21.8 - Prob. 58AYPCh. 21.8 - Prob. 59AYPCh. 21.8 - Prob. 60AYPCh. 21.8 - Prob. 61AYPCh. 21.8 - Prob. 62AYPCh. 21.9 - Prob. 63AYPCh. 21.9 - What are the two major control systems that...Ch. 21.9 - Prob. 65AYPCh. 21.9 - Elaborate on the adrenal medullary control...Ch. 21.9 - Prob. 67AYPCh. 21.9 - Prob. 68AYPCh. 21.9 - Prob. 69AYPCh. 21.9 - Prob. 70AYPCh. 21.9 - Prob. 71AYPCh. 21.9 - Prob. 72AYPCh. 21.9 - Prob. 73AYPCh. 21 - Prob. 1RACCh. 21 - Prob. 2RACCh. 21 - Prob. 3RACCh. 21 - Prob. 4RACCh. 21 - The structures that supply the walls of blood...Ch. 21 - Given these arteriae: (l) brailar (2) common...Ch. 21 - Prob. 7RACCh. 21 - A branch of the aorta that supplies the liver,...Ch. 21 - Prob. 9RACCh. 21 - Prob. 10RACCh. 21 - Blood returning fromthe arm to the subclavian vein...Ch. 21 - Given these blood vessels: (1) inferior mesenteric...Ch. 21 - Given these veins: (1) small saphenous (2) great...Ch. 21 - Prob. 14RACCh. 21 - Prob. 15RACCh. 21 - Veins a. increases their volume because of their...Ch. 21 - Prob. 17RACCh. 21 - Prob. 18RACCh. 21 - Prob. 19RACCh. 21 - Prob. 20RACCh. 21 - Prob. 21RACCh. 21 - Prob. 22RACCh. 21 - Prob. 23RACCh. 21 - Prob. 24RACCh. 21 - Prob. 25RACCh. 21 - Prob. 1CTCh. 21 - Prob. 2CTCh. 21 - Prob. 3CTCh. 21 - All the blood that passes through the aorta,...Ch. 21 - As blood vessels increase in diameter. the amount...Ch. 21 - A very short nursing student is asked to measure...Ch. 21 - Prob. 7CTCh. 21 - Prob. 8CTCh. 21 - Epinephrine causes vasodilation of blood vessels...Ch. 21 - Prob. 10CTCh. 21 - Prob. 11CT
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