SEELEY'S ANATOMY+PHYSIOLOGY
12th Edition
ISBN: 9781260172195
Author: VanPutte
Publisher: RENT MCG
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Textbook Question
Chapter 21.2, Problem 13AYP
In which type of blood vessels are valves found? What istheir function?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
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Chapter 21 Solutions
SEELEY'S ANATOMY+PHYSIOLOGY
Ch. 21.1 - What is the difference between pulmonary and...Ch. 21.1 - Describe the five functions of the circulatory...Ch. 21.2 - Prob. 3AYPCh. 21.2 - Prob. 4AYPCh. 21.2 - Prob. 5AYPCh. 21.2 - Prob. 6AYPCh. 21.2 - Prob. 7AYPCh. 21.2 - Describe a capillary network. Where is the smooth...Ch. 21.2 - Prob. 9AYPCh. 21.2 - Prob. 10AYP
Ch. 21.2 - Prob. 11AYPCh. 21.2 - Prob. 12AYPCh. 21.2 - In which type of blood vessels are valves found?...Ch. 21.2 - Prob. 14AYPCh. 21.2 - Prob. 15AYPCh. 21.2 - Prob. 16AYPCh. 21.3 - Prob. 17AYPCh. 21.4 - Name the parts of the aorta.Ch. 21.4 - Name the arteries that branch from the ascending...Ch. 21.4 - Prob. 20AYPCh. 21.4 - Prob. 21AYPCh. 21.4 - Prob. 22AYPCh. 21.4 - Prob. 23AYPCh. 21.4 - Name the two types of branches arising from the...Ch. 21.4 - Prob. 25AYPCh. 21.4 - Prob. 26AYPCh. 21.4 - Prob. 27AYPCh. 21.5 - Prob. 28AYPCh. 21.5 - What veins collect blood from the heart muscle.Ch. 21.5 - Prob. 30AYPCh. 21.5 - Prob. 31AYPCh. 21.5 - Prob. 32AYPCh. 21.5 - Prob. 33AYPCh. 21.5 - Prob. 34AYPCh. 21.5 - Prob. 35AYPCh. 21.6 - Prob. 36AYPCh. 21.6 - Prob. 37AYPCh. 21.6 - Prob. 38AYPCh. 21.6 - Prob. 39AYPCh. 21.6 - Prob. 40AYPCh. 21.6 - Prob. 41AYPCh. 21.6 - Prob. 42AYPCh. 21.6 - Prob. 43AYPCh. 21.7 - Prob. 44AYPCh. 21.7 - Describe the total cross-sectional areas of the...Ch. 21.7 - Describe how the rate changes as blood flows...Ch. 21.7 - Prob. 47AYPCh. 21.7 - Prob. 48AYPCh. 21.7 - Prob. 49AYPCh. 21.7 - What is pulse pressure? How do stroke volume and...Ch. 21.7 - Prob. 51AYPCh. 21.7 - Prob. 52AYPCh. 21.7 - Prob. 53AYPCh. 21.7 - Prob. 54AYPCh. 21.7 - Prob. 55AYPCh. 21.7 - Prob. 56AYPCh. 21.7 - Prob. 57AYPCh. 21.8 - Prob. 58AYPCh. 21.8 - Prob. 59AYPCh. 21.8 - Prob. 60AYPCh. 21.8 - Prob. 61AYPCh. 21.8 - Prob. 62AYPCh. 21.9 - Prob. 63AYPCh. 21.9 - What are the two major control systems that...Ch. 21.9 - Prob. 65AYPCh. 21.9 - Elaborate on the adrenal medullary control...Ch. 21.9 - Prob. 67AYPCh. 21.9 - Prob. 68AYPCh. 21.9 - Prob. 69AYPCh. 21.9 - Prob. 70AYPCh. 21.9 - Prob. 71AYPCh. 21.9 - Prob. 72AYPCh. 21.9 - Prob. 73AYPCh. 21 - Prob. 1RACCh. 21 - Prob. 2RACCh. 21 - Prob. 3RACCh. 21 - Prob. 4RACCh. 21 - The structures that supply the walls of blood...Ch. 21 - Given these arteriae: (l) brailar (2) common...Ch. 21 - Prob. 7RACCh. 21 - A branch of the aorta that supplies the liver,...Ch. 21 - Prob. 9RACCh. 21 - Prob. 10RACCh. 21 - Blood returning fromthe arm to the subclavian vein...Ch. 21 - Given these blood vessels: (1) inferior mesenteric...Ch. 21 - Given these veins: (1) small saphenous (2) great...Ch. 21 - Prob. 14RACCh. 21 - Prob. 15RACCh. 21 - Veins a. increases their volume because of their...Ch. 21 - Prob. 17RACCh. 21 - Prob. 18RACCh. 21 - Prob. 19RACCh. 21 - Prob. 20RACCh. 21 - Prob. 21RACCh. 21 - Prob. 22RACCh. 21 - Prob. 23RACCh. 21 - Prob. 24RACCh. 21 - Prob. 25RACCh. 21 - Prob. 1CTCh. 21 - Prob. 2CTCh. 21 - Prob. 3CTCh. 21 - All the blood that passes through the aorta,...Ch. 21 - As blood vessels increase in diameter. the amount...Ch. 21 - A very short nursing student is asked to measure...Ch. 21 - Prob. 7CTCh. 21 - Prob. 8CTCh. 21 - Epinephrine causes vasodilation of blood vessels...Ch. 21 - Prob. 10CTCh. 21 - Prob. 11CT
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