FUNDAMENTALS OF BIOCHEMISTRY - LL FD
5th Edition
ISBN: 9781119598022
Author: Voet
Publisher: WILEY
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Chapter 21, Problem 9E
Summary Introduction
To draw: The reactions that convert tiglyl-CoA to acetyl-CoA and propionyl-CoA in the degradation pathway for isoleucine.
Concept introduction:
L-isoleucine is an important branched-chain amino acid. The degradation pathway of L-isoleucine is present in many plants, animals, and microorganisms. The end result of the degradative pathway is the formation of propionyl-CoA and acetyl-CoA.
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Extracts from the bacterium Bacillus brevis contain a peptide with antibiotic properties. This peptide forms complexes with
metal ions and seems to disrupt ion transport across the cell membranes of other bacterial species, leading to bacterial death.
The structure of the peptide has been determined from a series of observations.
(a) Complete acid hydrolysis of the peptide, followed by amino acid analysis, yielded equimolar amounts of Leu, Orn, Phe, Pro,
and Val. Orn is ornithine, an amino acid not present in proteins but present in some peptides. Orn has the structure
H
'H,N-CH,
-
CH2 CH2 CH2 -
C - COO-
NH,
(b) The molecular weight of the peptide is approximately 1,200 Da.
(c) The peptide failed to undergo hydrolysis when treated with the enzyme carboxypeptidase. This enzyme catalyzes the
hydrolysis of the carboxyl-terminal residue of a polypeptide unless the residue is Pro or the peptide does not contain a free
carboxyl group.
(d) Treatment of the intact peptide with…
At a pH equal to the isoelectric point (pl) of alanine, the net charge of alanine is zero. Two structures can be drawn that have a
net charge of zero, but the predominant form of alanine at its pl is zwitterionic.
CH3
H,N
CH3
**
H¸N-C
H
Zwitterionic
H
Uncharged
OH
Select statements that explain why alanine is predominantly zwitterionic at its pl.
pk of alanine's amino group is more than its pl.
pk of alanine's carboxyl group is more than its pl.
PK of alanine's carboxyl group is less than its pl.
pk of alanine's amino group is less than its pl.
Correct Answer
What fraction of alanine is in the completely uncharged form at its pl?
1 in 2.2 × 107
1 in 1.6 × 10²
1 in 4680
1 in 9460
How does a voltage-gated sodium channel work? Specifically, how and why does a change in voltage trigger their opening? Please be detailed
Chapter 21 Solutions
FUNDAMENTALS OF BIOCHEMISTRY - LL FD
Ch. 21 - Prob. 1ECh. 21 - 2. The compound shown below inhibits an...Ch. 21 - Prob. 3ECh. 21 - Prob. 4ECh. 21 - 5. Explain why it was advantageous for human...Ch. 21 - Prob. 6ECh. 21 - 7. Which of the 20 “standard” amino acids are (a)...Ch. 21 - 8. Alanine, cysteine, glycine, serine, and...Ch. 21 - Prob. 9ECh. 21 - 10. Draw the amino acid-Schiff base that forms in...
Ch. 21 - Prob. 11ECh. 21 - Prob. 12ECh. 21 - 13. Which three mammalian enzymes can potentially...Ch. 21 - Prob. 14ECh. 21 - Prob. 15ECh. 21 - Prob. 16ECh. 21 - Prob. 17ECh. 21 - Prob. 18ECh. 21 - Prob. 19ECh. 21 - 20. From what amino acid is the signaling molecule...Ch. 21 - Prob. 21ECh. 21 - Prob. 22ECh. 21 - 23. Describe the reactions that convert...Ch. 21 - Prob. 24ECh. 21 - 25. One of the symptoms of kwashiorkor, the...Ch. 21 - 26. From what amino acid is melatonin derived?...Ch. 21 - Prob. 27ECh. 21 - 28. Nitrosomonas is a photophobic (light-avoiding)...Ch. 21 - Prob. 29CQCh. 21 - Prob. 30CQCh. 21 - 31. (a) How many ATP equivalents are consumed by...Ch. 21 - Prob. 32CQCh. 21 - Prob. 33CQCh. 21 - Prob. 34CQCh. 21 - Prob. 35CQCh. 21 - Prob. 36CQCh. 21 - 37. The nucleotide deoxyuridylate (dUMP) is...Ch. 21 - 38. Proliferating cells require NADPH for...Ch. 21 - 39. Mouse embryonic stem cells produce high levels...Ch. 21 - 40. Rice plants that have been engineered to...Ch. 21 - Prob. 41CQCh. 21 - Prob. 1MTE
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- Calculate the standard change in Gibbs free energy, AGrxn, for the given reaction at 25.0 °C. Consult the table of thermodynamic properties for standard Gibbs free energy of formation values. NH,Cl(s) →NH; (aq) + C1 (aq) AGrxn -7.67 Correct Answer Determine the concentration of NH+ (aq) if the change in Gibbs free energy, AGrxn, for the reaction is -9.27 kJ/mol. 6.49 [NH+] Incorrect Answer kJ/mol Marrow_forwardWhat are some topics of interest that neurotoxicologists study? For example, toxin-induced seizures, brain death, and such along those lines?arrow_forwardCould you help me with the explanation of the answer to exercise 15, chapter 1 of Lehinger Question Nombramiento de estereoisómeros con dos carbonos quirales utilizando el sistema RS(R,R)El isómero del metilfenidato (Ritalin) se utiliza para tratar el trastorno por déficit de atención con hiperactividad (TDAH).(S,S)El isómero es un antidepresivo. Identifique los dos carbonos quirales en la siguiente estructura. ¿Es este el(R,R)o el(S,S)¿isómero? Dibuja el otro isómero. Nombramiento de estereoisómeros con dos carbonos quirales utilizando el sistema RS(R,R)El isómero del metilfenidato (Ritalin) se utiliza para tratar el trastorno por déficit de atención con hiperactividad (TDAH).(S,S)El isómero es un antidepresivo.arrow_forward
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