Chapter 21, Problem 74P

Interpretation Introduction

Interpretation:

Reason for the greater equilibrium constant for the oxidation of $\text{dithiothreitol}$ than oxidation of $\text{2-mercaptoethanol}$ should be explained.

Concept introduction:

Oxidation of thiols to disulfide: Oxidation of thiols lead to the formation of disulfide which contain a $\text{S}-\text{S}$ bond. The reagents which can be used for this reaction is either ${\text{Br}}_{\text{2}}\text{or}{\text{I}}_{\text{2}}$ in a basic solution.

Reduction of disulfide to thiol is also possible.