The synthesis of anastrozole from the given compounds is to be devised. Concept introduction: Alkylation of aldehydes and ketones takes place in the presence of a strong base. The use of appropriate base, solvent and temperature can yield one major product regioselectively. The first step is abstraction of proton and second step is attack of electrophile to form alkylated product. N-bromosuccinimide in the presence of peroxide undergoes bromination on allylic and benzylic positions.

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Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 21, Problem 65P

Interpretation Introduction

Interpretation: The synthesis of anastrozole from the given compounds is to be devised.

Concept introduction: Alkylation of aldehydes and ketones takes place in the presence of a strong base. The use of appropriate base, solvent and temperature can yield one major product regioselectively.

The first step is abstraction of proton and second step is attack of electrophile to form alkylated product. N-bromosuccinimide in the presence of peroxide undergoes bromination on allylic and benzylic positions.

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PROBLEM 4 Solved Show how 1-butanol can be converted into the following compounds: a. PROBLEM 5+ b. d. -C= N

Which alkene is the major product of this dehydration? OH H2SO4 heat

Answer 2

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Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 21, Problem 65P

Interpretation Introduction

Interpretation: The synthesis of anastrozole from the given compounds is to be devised.

Concept introduction: Alkylation of aldehydes and ketones takes place in the presence of a strong base. The use of appropriate base, solvent and temperature can yield one major product regioselectively.

The first step is abstraction of proton and second step is attack of electrophile to form alkylated product. N-bromosuccinimide in the presence of peroxide undergoes bromination on allylic and benzylic positions.

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Answer 3

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Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 21, Problem 65P

Interpretation Introduction

Interpretation: The synthesis of anastrozole from the given compounds is to be devised.

Concept introduction: Alkylation of aldehydes and ketones takes place in the presence of a strong base. The use of appropriate base, solvent and temperature can yield one major product regioselectively.

The first step is abstraction of proton and second step is attack of electrophile to form alkylated product. N-bromosuccinimide in the presence of peroxide undergoes bromination on allylic and benzylic positions.

Expert Solution & Answer

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Answer 4

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Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 21, Problem 65P

Interpretation Introduction