Chapter 21, Problem 36P

Interpretation Introduction

(a)

Interpretation: The major enolate formed by the treatment of given compound with LDA is to be identified.

Concept introduction: Lithium diisopropylamide (LDA), molecular formula ${\left[{\left({\text{CH}}_{\text{3}}\right)}_{\text{2}}\text{CH}\right]}_{\text{2}}\text{NLi}$ is a strong base and has been widely accepted due to its good solubility in non-polar organic solvent. It is a bulky base which usually extracts hydrogen from less hindered carbon.

Interpretation Introduction

(b)

Interpretation: The major enolate formed by the treatment of given compound with LDA is to be identified.

Concept introduction: Lithium diisopropylamide (LDA), molecular formula ${\left[{\left({\text{CH}}_{\text{3}}\right)}_{\text{2}}\text{CH}\right]}_{\text{2}}\text{NLi}$ is a strong base and has been widely accepted due to its good solubility in non-polar organic solvent. It is a bulky base which usually extracts hydrogen from less hindered carbon.

Interpretation Introduction

(c)

Interpretation: The major enolate formed by the treatment of given compound with LDA is to be identified.

Concept introduction: Lithium diisopropylamide (LDA), molecular formula ${\left[{\left({\text{CH}}_{\text{3}}\right)}_{\text{2}}\text{CH}\right]}_{\text{2}}\text{NLi}$ is a strong base and has been widely accepted due to its good solubility in non-polar organic solvent. It is a bulky base which usually extracts hydrogen from less hindered carbon.

Interpretation Introduction

(d)

Interpretation: The major enolate formed by the treatment of given compound with LDA is to be identified.

Concept introduction: Lithium diisopropylamide (LDA), molecular formula ${\left[{\left({\text{CH}}_{\text{3}}\right)}_{\text{2}}\text{CH}\right]}_{\text{2}}\text{NLi}$ is a strong base and has been widely accepted due to its good solubility in non-polar organic solvent. It is a bulky base which usually extracts hydrogen from less hindered carbon.