BENSON'S MICROBIOLOGY LAB CONCISE, LL+AC
14th Edition
ISBN: 9781264639892
Author: Brown
Publisher: MCG
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Chapter 21, Problem 5SAQ
Summary Introduction
To compare and contrast: Bacteriophage plaque with bacterial colonies.
Introduction: A virus is a small infectious agent that only replicates inside the living cells of an organism. It is made up of a core of genetic material, either RNA or DNA, surrounded by a protective coat called capsid. A bacteriophage is a virus that infects and replicates within archaea and bacteria. Bacteriophages infect bacteria but are harmless to humans.
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Biopharmaceutics and Pharmacokinetics:Two-Compartment Model Instant Absorption Questions
SHOW ALL WORK, including equation used, variables used and each step to your solution, report your regression lines and axes names (with units if appropriate) :Calculate a-q
a) B1,
b) B2,
c) hybrid rate constant (1)
d) hybrid rate constant (2)
e) t1/2,dist
f) t1/2,elim
g) k10
h) k12
i) k21
j) initial concentration (C0)
k) central compartment volume (V1)
l) steady-state volume (Vss)
m) clearance (CL) AUC (0→10 min) using trapezoidal rule
n) AUC (20→30 min) using trapezoidal rule
o) AUCtail (AUC360→∞)
p) total AUC (using short cut method)
q) volume from AUC (VAUC)
Glitazones reduce insulin resistance by binding to a transcription factor in adipocytes, thereby reducing thesecretion of fatty acids. Glitazones are taken orally (in pill form). Using pharmacokinetic modeling, deriveequations to describe how the concentration of glitazones varies in the plasma as a function of time. Yourequations should be of the form: dCglitazone /dt = something, or dMglitazone /dt = something. Your model shouldinclude three compartments: the gut, the plasma, and the fatty tissues. Make sure to include a diagram thatillustrates your thinking, state all assumptions, and define your variables. Do not solve the equations.
Chapter 21 Solutions
BENSON'S MICROBIOLOGY LAB CONCISE, LL+AC
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