Chapter 21, Problem 4P

(a)

Summary Introduction

To determine: The [2-H²] acetyl-CoA and an excess of unlabeled malonyl-CoA are added as substrate, the number of deuterium atoms which are incorporated into every molecule of palmitate, and their location.

Introduction:

Fatty acid synthesis is the common pathway which uses acetyl-CoA as substrate for fatty acid synthesis. It occurs in the cytoplasm of the cell. Fatty acid synthases help in fatty acids synthesis from acetyl-CoA and NADPH.

(b)

Summary Introduction

To determine:

The unlabeled acetyl-CoA and [2-²H] acetyl-CoA are added as substrates, the number of deuterium atoms are incorporated into every molecule of palmitate and their location is to be explained.

Introduction:

Fatty acid synthesis is the common pathway which use $\text{acetyl-CoA}$ as substrate for fatty acid synthesis. It occurs in the cytoplasm of the cell. Acetyl-CoA and NADPH produces fatty acids in the presence of enzyme fatty acid synthases.