Fundamentals of Biochemistry: Life at the Molecular Level
Fundamentals of Biochemistry: Life at the Molecular Level
5th Edition
ISBN: 9781118918401
Author: Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher: WILEY
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Chapter 21, Problem 4E
Summary Introduction

To explain: The reason behind the dual inhibitory effect could contribute to the neurotoxic side effects of long-term ritonavir usage.

Concept introduction: Ritonavir is an antiretroviral drug that is used to treat Human Immunodeficiency virus (HIV) infection or Acquired Immunodeficiency Syndrome (AIDS). It was developed mainly to inhibit the HIV protease. Proteosomes refers to the protein complexes that are considered to degrade the unnecessary proteins using proteolysis.

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