
52-Year-Old Male with Multiple Sclerosis
Mr. Ayers was diagnosed with an aggressive form of multiple sclerosis 18 years ago. His illness has not responded to conventional treatments so he's been referred to your clinic for a clinical trial.
The doctor explains that his treatment will involve giving Mr. Ayers a drug that will release stem cells from his bone marrow so they can be collected from his blood. Then Mr. Ayers will be given (1) drugs that will destroy the blood-forming cells in his bone marrow, and (2), antibodies against his T lymphocytes. Finally, the stem cells that were collected from him will be used to repopulate his bone marrow.
The doctor says, “This treatment avoids problems, such as transplant rejection, that are associated with other kinds of transplants.”
2. One reason for using Mr. Ayers's own tissue is that it can be very difficult to find a donor whose bone marrow cells match the patient's class I and II MHC proteins. What is an MHC protein? What is the difference between class I and class II MHC proteins?

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Chapter 21 Solutions
Human Anatomy & Physiology Plus Modified Mastering A&P with Pearson eText -- Access Card Package 11th edition
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- Choose a catecholamine neurotransmitter and describe/draw the components of the synapse important for its signaling including synthesis, packaging into vesicles, receptors, transporters/degradative enzymes. Describe 2 drugs that can act on this system.arrow_forwardThe following figure is from Caterina et al. The capsaicin receptor: a heat activated ion channel in the pain pathway. Nature, 1997. Black boxes indicate capsaicin, white circles indicate resinferatoxin. a) Which has a higher potency? b) Which is has a higher efficacy? c) What is the approximate Kd of capsaicin in uM? (you can round to the nearest power of 10)arrow_forwardWhat is the rate-limiting-step for serotonin synthesis?arrow_forward
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