BIOLOGY 2E
2nd Edition
ISBN: 9781506699851
Author: OpenStax
Publisher: XANEDU PUBLISHING
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Chapter 21, Problem 23CTQ
Varicella-zoster virus is a double-stranded DNA virus that causes chickenpox. How does its genome structure provide an evolutionary advantage over a single-stranded DNA virus?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 21 Solutions
BIOLOGY 2E
Ch. 21 - Figure 21.5 Which of the following statements...Ch. 21 - Figure 21.8 Influenza virus is packaged in a viral...Ch. 21 - Figure 21.10 Which of the following statements is...Ch. 21 - Which statement is true? A virion contains DNA and...Ch. 21 - The viral______play(s) a role in attaching a...Ch. 21 - Viruses. all have a round shape cannot have a long...Ch. 21 - The observation that the bacteria genus Chlamydia...Ch. 21 - A scientist discovers a new virus with a linear,...Ch. 21 - Which statement is not true of viral replication?...Ch. 21 - Which statement is true of viral replication? In...
Ch. 21 - Which statement is true of reverse transcriptase?...Ch. 21 - Oncogenic virus cores can be. RNA DNA neither RNA...Ch. 21 - Which is true of DNA viruses? They use the host...Ch. 21 - A bacteriophage can infect the lungs viruses...Ch. 21 - People with the CCR5?32 mutation of a T-cell...Ch. 21 - An apple grower notices that several of his apple...Ch. 21 - Which of the following is NOT used to treat active...Ch. 21 - Vaccines. are similar to viroids are only needed...Ch. 21 - A patient presents at the clinic with an acute...Ch. 21 - Which of the following is not associated with...Ch. 21 - Which statement is true of viroids? They are...Ch. 21 - The first electron micrograph of a virus (tobacco...Ch. 21 - Varicella-zoster virus is a double-stranded DNA...Ch. 21 - Classify the Rabies virus (a rhabdovirus family...Ch. 21 - Why can’t dogs catch the measles?Ch. 21 - One of the first and most important targets for...Ch. 21 - In this section, you were introduced to different...Ch. 21 - Although plant viruses cannot infect humans, what...Ch. 21 - A bacteriophage with a lytic life cycle develops a...Ch. 21 - Why is immunization after being bitten by a rabid...Ch. 21 - The vaccine Gardasil that targets human papilloma...Ch. 21 - Prions are responsible for variant Creutzfeldt...Ch. 21 - How are viroids like viruses?Ch. 21 - A botanist notices that a tomato plant looks...
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