Becker's World of the Cell (9th Edition)
9th Edition
ISBN: 9780321934925
Author: Jeff Hardin, Gregory Paul Bertoni
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 21, Problem 21.4PS
Tay-Sachs Screening. In a certain community, a mutant allele for Tay-Sachs disease (the gene encoding the enzyme hexosaminidase A) exists at a high frequency. This mutation removes a HindIII restriction site (H) in the gene. A probe is available for this region, as shown in Figure 21-33a. Two couples in this community are expecting children. Each couple has a prenatal DNA test to determine if their child will have Tay-Sachs. The results of a Southern blot using HindII digested DNA probed for the region are shown in Figure 21-33b. What advice would you give to each couple in terms of preparing for a child with Tay-Sachs?
(a) Gene structure and probe location
(b) Southern blot
Figure 21-33 Using Southern Blots to Analyze Patients for Tay-Sachs. See Problem 21-4.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Give the terminal regression line equation and R or R2 value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the first residual regression line equation and R or R2 value:
Give the x axis (name and units, if any) of the first residual line
: Give the y axis (name and units, if any) of the first residual line:
Give the second residual regression line equation and R or R2 value:
Give the x axis (name and units, if any) of the second residual line:
Give the y axis (name and units, if any) of the second residual line:
a) B1
Solution
b) B2
c)hybrid rate constant (λ1)
d)hybrid rate constant (λ2)
e) ka
f) t1/2,absorb
g) t1/2, dist
h) t1/2, elim
i)apparent central compartment volume (V1,app)
j) total AUC (short cut method)
k) apparent volume of distribution based on AUC (VAUC,app)
l)apparent clearance (CLapp)
m) absolute bioavailability of oral route (need AUCiv…
You inject morpholino oligonucleotides that inhibit the translation of follistatin, chordin, and noggin (FCN) at the 1 cell stage of a frog embryo.
What is the effect on neurulation in the resulting embryo?
Propose an experiment that would rescue an embryo injected with FCN morpholinos.
Participants will be asked to create a meme regarding a topic relevant to the department of Geography, Geomatics, and Environmental Studies.
Prompt: Using an online art style of your choice, please make a meme related to the study of Geography, Environment, or Geomatics.
Chapter 21 Solutions
Becker's World of the Cell (9th Edition)
Ch. 21 - Antibiotics such as ampicillin are inactivated by...Ch. 21 - By weight, spider silk is stronger than steel, so...Ch. 21 - What are the similarities and differences between...Ch. 21 - Prob. 21.3CCCh. 21 - Prob. 21.4CCCh. 21 - Prob. 21.1PSCh. 21 - Prob. 21.2PSCh. 21 - Prob. 21.3PSCh. 21 - Tay-Sachs Screening. In a certain community, a...Ch. 21 - Library Science. You have constructed DNA probes...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Plekhg5 functions in bottle cell formation, and Shroom3 functions in neural plate closure, yet the phenotype of injecting mRNA of each into the animal pole of a fertilized egg is very similar. What is the phenotype, and why is the phenotype so similar? Is the phenotype going to be that there is a disruption of the formation of the neural tube for both of these because bottle cell formation is necessary for the neural plate to fold in forming the neural tube and Shroom3 is further needed to close the neural plate? So since both Plekhg5 and Shroom3 are used in forming the neural tube, injecting the mRNA will just lead to neural tube deformity?arrow_forwardWhat are some medical issues or health trends that may have a direct link to the idea of keeping fat out of diets?arrow_forwardwhat did charles darwin do in sciencearrow_forward
- fa How many different gametes, f₂ phenotypes and f₂ genotypes can potentially be produced from individuals of the following genotypes? 1) AaBb i) AaBB 11) AABSC- AA Bb Cc Dd EE Cal bsm nortubaarrow_forwardC MasteringHealth MasteringNu × session.healthandnutrition-mastering.pearson.com/myct/itemView?assignment ProblemID=17396416&attemptNo=1&offset=prevarrow_forward10. Your instructor will give you 2 amino acids during the activity session (video 2-7. A. First color all the polar and non-polar covalent bonds in the R groups of your 2 amino acids using the same colors as in #7. Do not color the bonds in the backbone of each amino acid. B. Next, color where all the hydrogen bonds, hydrophobic interactions and ionic bonds could occur in the R group of each amino acid. Use the same colors as in #7. Do not color the bonds in the backbone of each amino acid. C. Position the two amino acids on the page below in an orientation where the two R groups could bond together. Once you are satisfied, staple or tape the amino acids in place and label the bond that you formed between the two R groups. - Polar covalent Bond - Red - Non polar Covalent boND- yellow - Ionic BonD - PINK Hydrogen Bonn - Purple Hydrophobic interaction-green O=C-N H I. H HO H =O CH2 C-C-N HICK H HO H CH2 OH H₂N C = Oarrow_forwardFind the dental formula and enter it in the following format: I3/3 C1/1 P4/4 M2/3 = 42 (this is not the correct number, just the correct format) Please be aware: the upper jaw is intact (all teeth are present). The bottom jaw/mandible is not intact. The front teeth should include 6 total rectangular teeth (3 on each side) and 2 total large triangular teeth (1 on each side).arrow_forward12. Calculate the area of a circle which has a radius of 1200 μm. Give your answer in mm² in scientific notation with the correct number of significant figures.arrow_forwardDescribe the image quality of the B.megaterium at 1000X before adding oil? What does adding oil do to the quality of the image?arrow_forwardarrow_back_iosSEE MORE QUESTIONSarrow_forward_ios
Recommended textbooks for you
Biology Today and Tomorrow without Physiology (Mi...BiologyISBN:9781305117396Author:Cecie Starr, Christine Evers, Lisa StarrPublisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning
Biology Today and Tomorrow without Physiology (Mi...
Biology
ISBN:9781305117396
Author:Cecie Starr, Christine Evers, Lisa Starr
Publisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
QCE Biology: Introduction to Gene Expression; Author: Atomi;https://www.youtube.com/watch?v=a7hydUtCIJk;License: Standard YouTube License, CC-BY