Bundle: Introduction to General, Organic and Biochemistry, 11th + OWLv2, 4 terms (24 months) Printed Access Card
11th Edition
ISBN: 9781305705159
Author: Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher: Cengage Learning
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Chapter 21, Problem 21.35P
Interpretation Introduction
Interpretation:
The ring of the steroid structure undergoes the most substitution in cholesterol needs to be identified.
Concept introduction:
The fat-like substance in the body is known as Cholesterol. It is formed by our body and also present in food. Though it is required for good health, large amount of cholesterol can harm our arteries and increase heart disease risk.
Various steroid hormones are synthesized from cholesterol as starting materials. The aliphatic side chain on the D ring undergoes a chain-shortening reaction and the hydroxyl group is oxidized to a
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Learning Goal:
As discussed during the lecture, the enzyme HIV-1 reverse transcriptae (HIV-RT) plays a significant role for the HIV virus and is an important drug target. Assume a concentration [E] of 2.00 µM (i.e. 2.00 x 10-6 mol/l) for HIV-RT. Two potential drug molecules, D1 and D2, were identified, which form stable complexes with the HIV-RT.
The dissociation constant of the complex ED1 formed by HIV-RT and the drug D1 is 1.00 nM (i.e. 1.00 x 10-9). The dissociation constant of the complex ED2 formed by HIV-RT and the drug D2 is 100 nM (i.e. 1.00 x 10-7).
Part A - Difference in binding free eenergies
Compute the difference in binding free energy (at a physiological temperature T=310 K) for the complexes. Provide the difference as a positive numerical expression with three significant figures in kJ/mol.
The margin of error is 2%.
Part B - Compare difference in free energy to the thermal energy
Divide the…
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Chapter 21 Solutions
Bundle: Introduction to General, Organic and Biochemistry, 11th + OWLv2, 4 terms (24 months) Printed Access Card
Ch. 21.8 - Prob. 21.1PCh. 21 - 21-2 Why are fats a good source of energy for...Ch. 21 - 21-3 Proteins, nucleic acids, and carbohydrates...Ch. 21 - Prob. 21.4PCh. 21 - Prob. 21.5PCh. 21 - Prob. 21.6PCh. 21 - 21-7 For the diglycerides in Problem 21-6, predict...Ch. 21 - 21-8 Predict which acid in each pair has the...Ch. 21 - Prob. 21.9PCh. 21 - Prob. 21.10P
Ch. 21 - Prob. 21.11PCh. 21 - Prob. 21.12PCh. 21 - 21-13 Rank the following in order of increasing...Ch. 21 - Prob. 21.14PCh. 21 - 21-15 Name the products of the saponification of...Ch. 21 - Prob. 21.16PCh. 21 - Prob. 21.17PCh. 21 - Prob. 21.18PCh. 21 - Prob. 21.19PCh. 21 - Prob. 21.20PCh. 21 - Prob. 21.21PCh. 21 - Prob. 21.22PCh. 21 - Prob. 21.23PCh. 21 - 21-24 In what sense is the active transport of K+...Ch. 21 - Prob. 21.25PCh. 21 - Prob. 21.26PCh. 21 - Prob. 21.27PCh. 21 - Prob. 21.28PCh. 21 - 21-29 Name all the groups of complex lipids that...Ch. 21 - Prob. 21.30PCh. 21 - Prob. 21.31PCh. 21 - Prob. 21.32PCh. 21 - Prob. 21.33PCh. 21 - Prob. 21.34PCh. 21 - Prob. 21.35PCh. 21 - Prob. 21.36PCh. 21 - Prob. 21.37PCh. 21 - Prob. 21.38PCh. 21 - 21-39 How does VLDL become LDL?Ch. 21 - Prob. 21.40PCh. 21 - Prob. 21.41PCh. 21 - Prob. 21.42PCh. 21 - Prob. 21.43PCh. 21 - 21-44 Describe the difference in structure between...Ch. 21 - Prob. 21.45PCh. 21 - Prob. 21.46PCh. 21 - Prob. 21.47PCh. 21 - 21-48 List all of the functional groups that make...Ch. 21 - 21-49 Explain how the constant elimination of bile...Ch. 21 - Prob. 21.50PCh. 21 - Prob. 21.51PCh. 21 - 21-52 What are the chemical and physiological...Ch. 21 - 21-53 How does aspirin, an anti-inflammatory drug,...Ch. 21 - Prob. 21.54PCh. 21 - Prob. 21.55PCh. 21 - Prob. 21.56PCh. 21 - Prob. 21.57PCh. 21 - Prob. 21.58PCh. 21 - Prob. 21.59PCh. 21 - 21-60 (Chemical Connections 21C) Why were Mark...Ch. 21 - Prob. 21.61PCh. 21 - Prob. 21.62PCh. 21 - Prob. 21.63PCh. 21 - Prob. 21.64PCh. 21 - Prob. 21.65PCh. 21 - Prob. 21.66PCh. 21 - Prob. 21.67PCh. 21 - 21-68 What is the role of taurine in lipid...Ch. 21 - Prob. 21.69PCh. 21 - 21-70 How many different triglycerides can you...Ch. 21 - Prob. 21.71PCh. 21 - Prob. 21.72PCh. 21 - Prob. 21.73PCh. 21 - Prob. 21.74PCh. 21 - Prob. 21.75PCh. 21 - 21-76 Which part of LDL interacts with the LDL...Ch. 21 - Prob. 21.77PCh. 21 - Prob. 21.78PCh. 21 - Prob. 21.79PCh. 21 - Prob. 21.80PCh. 21 - Prob. 21.81PCh. 21 - 21-82 Suggest a reason why the same protein system...Ch. 21 - Prob. 21.83PCh. 21 - Prob. 21.84PCh. 21 - 21-85 Which of the following statements is (are)...Ch. 21 - Prob. 21.86PCh. 21 - 21-87 Which statements are consistent with the...Ch. 21 - Prob. 21.88PCh. 21 - Prob. 21.89PCh. 21 - 21-90 To what extent do lipids and carbohydrates...Ch. 21 - Prob. 21.91PCh. 21 - Prob. 21.92PCh. 21 - Prob. 21.93PCh. 21 - Prob. 21.94PCh. 21 - Prob. 21.95PCh. 21 - Prob. 21.96PCh. 21 - Prob. 21.97PCh. 21 - Prob. 21.98PCh. 21 - Prob. 21.99PCh. 21 - 21-100 What are the functions of a cell membrane?...Ch. 21 - 21-101 Glycerophospholipids tend to have both a...Ch. 21 - Prob. 21.102P
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