The amino acid sequence of the normal and the mutant proteins when a gene containing the sequences AUGCCCGACUUU undergoes point mutation to give the gene AUGCC G _ GACUUU has to be determined. Also the type of point mutation has to be identified. Concept Introduction: The point mutation is defined as the mutation that results from the replacement of single nucleotide from the codon triplet. For instance, if the UUU codon that codes for phenylalanine.is replaced by the codon UUA it would code for leucine. Silent mutations are the point mutations that do not affect the amino acid being encoded. For example, a silent mutation that results in the replacement of leucine with isoleucine has no significant effect on the protein’s function as isoleucine uses the same functionality as that of leucine.

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Chapter 20.7, Problem 20.12Q

Interpretation Introduction

Interpretation:

The amino acid sequence of the normal and the mutant proteins when a gene containing the sequences AUGCCCGACUUU undergoes point mutation to give the gene AUGCCG_GACUUU has to be determined. Also the type of point mutation has to be identified.

Concept Introduction:

The point mutation is defined as the mutation that results from the replacement of single nucleotide from the codon triplet. For instance, if the UUU codon that codes for phenylalanine.is replaced by the codon UUA it would code for leucine.

Silent mutations are the point mutations that do not affect the amino acid being encoded. For example, a silent mutation that results in the replacement of leucine with isoleucine has no significant effect on the protein’s function as isoleucine uses the same functionality as that of leucine.

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