MOLECULAR BIOLOGY OF THE CELL (LL)
MOLECULAR BIOLOGY OF THE CELL (LL)
6th Edition
ISBN: 9780393876109
Author: ALBERTS
Publisher: NORTON
bartleby

Concept explainers

bartleby

Videos

Question
Book Icon
Chapter 20, Problem 7P

A.

Summary Introduction

To explain: The model which accounts more readily for the features of the highly rearranged chromosomes.

Concept introduction: Chromosomal aberrations are changes in the normal structure of chromosome by addition, deletion, inversion and translocation. Chromosomal aberrations results in change in the gene order and inactivation of genes. If the genes involved in cell cycle are inactivated then cell cycle errors occurs which leads to cancer cells. There are two models regarding rearrangement of chromosomes which are studied that account for 2 to 3 % of all cancers which includes: Progressive Rearrangements Model (PRM) and Chromosome Catastrophe Model (CCM). Progressive Rearrangements model is where continuous chromosomal aberrations take place and several genes are rearranged. Chromosome Catastrophe Model is where the chromosome gets broken into several fragments and then stitched back together by Non Homologous End Joining (NHEJ).

B.

Summary Introduction

To explain: The way in which multiple chromosomal rearrangements arise.

Concept introduction: Chromosomal aberrations are changes in the normal structure of chromosome by addition, deletion, inversion and translocation. Chromosomal aberrations results in change in the gene order and inactivation of genes. If the genes involved in cell cycle are inactivated then cell cycle errors occurs which leads to cancer cells. There are two models regarding rearrangement of chromosomes which are studied that account for 2 to 3 % of all cancers which includes: Progressive Rearrangements Model (PRM) and Chromosome Catastrophe Model (CCM).

C.

Summary Introduction

To explain: The arrangements are likely causative agents of cancers in which they have found or the rearrangements are just passenger events that are unrelated to cancer.

Concept introduction: Chromosomal aberrations are changes in the normal structure of chromosome by addition, deletion, inversion and translocation. Chromosomal aberrations results in change in the gene order and inactivation of genes. If the genes involved in cell cycle are inactivated then cell cycle errors occurs which leads to cancer cells. There are two models regarding rearrangement of chromosomes which are studied that account for 2 to 3 % of all cancers which includes: Progressive Rearrangements Model (PRM) and Chromosome Catastrophe Model (CCM).

Summary Introduction

To explain: The way in which chromosome rearrangements activate an oncogene or inactivate tumor suppressor gene.

Concept introduction: Chromosomal aberrations are changes in the normal structure of chromosome by addition, deletion, inversion and translocation. Chromosomal aberrations results in change in the gene order and inactivation of genes. If the genes involved in cell cycle are inactivated then cell cycle errors occurs which leads to cancer cells. There are two models regarding rearrangement of chromosomes which are studied that account for 2 to 3 % of all cancers which includes: Progressive Rearrangements Model (PRM) and Chromosome Catastrophe Model (CCM).

Blurred answer
Students have asked these similar questions
You aim to test the hypothesis that the Tbx4 and Tbx5 genes inhibit each other's expression during limb development. With access to chicken embryos and viruses capable of overexpressing Tbx4 and Tbx5, describe an experiment to investigate whether these genes suppress each other's expression in the limb buds. What results would you expect if they do repress each other? What results would you expect if they do not repress each other?
You decide to delete Fgf4 and Fgf8 specifically in the limb bud. Explain why you would not knock out these genes in the entire embryo instead.
You implant an FGF10-coated bead into the anterior flank of a chicken embryo, directly below the level of the wing bud. What is the phenotype of the resulting ectopic limb?  Briefly describe the expected expression domains of 1) Shh, 2) Tbx4, and 3) Tbx5 in the resulting ectopic limb bud.
Knowledge Booster
Background pattern image
Biology
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
SEE MORE QUESTIONS
Recommended textbooks for you
Text book image
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:PEARSON
Text book image
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Text book image
Anatomy & Physiology
Biology
ISBN:9781259398629
Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:Mcgraw Hill Education,
Text book image
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:9780815344322
Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:W. W. Norton & Company
Text book image
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:9781260159363
Author:Martin, Terry R., Prentice-craver, Cynthia
Publisher:McGraw-Hill Publishing Co.
Text book image
Inquiry Into Life (16th Edition)
Biology
ISBN:9781260231700
Author:Sylvia S. Mader, Michael Windelspecht
Publisher:McGraw Hill Education
QCE Biology: Introduction to Gene Expression; Author: Atomi;https://www.youtube.com/watch?v=a7hydUtCIJk;License: Standard YouTube License, CC-BY