Chapter 20, Problem 73P

Interpretation Introduction

Interpretation:

Prostaglandins have a five-membered ring closure, thromboxanes have a six-membered ring closure. The synthesis of both groups of compounds is prevented by COX inhibitors, the COX enzymes catalyze ring closure. The relation between these facts should be correlated.

Concept introduction:

The enzyme which catalyzes the reaction of ring closure for prostaglandin is known as cyclooxygenase, or COX. The COX enzyme is present in the body in two different forms, COX-1, and COX-2.