Concepts of Genetics Plus Mastering Genetics with Pearson eText -- Access Card Package (12th Edition) (What's New in Genetics)
Concepts of Genetics Plus Mastering Genetics with Pearson eText -- Access Card Package (12th Edition) (What's New in Genetics)
12th Edition
ISBN: 9780134811390
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 20, Problem 33ESP

The U.S. Department of Justice has established a database that catalogs PCR amplification products from short tandem repeats of the Y chromosome (Y-STRs) in humans. The database contains polymorphisms of five U.S. ethnic groups (African-Americans, European Americans, Hispanics, Native Americans, and Asian-Americans) as well as the worldwide population.

  1. (a) Given that STRs are repeats of varying lengths, for example (TCTG)9-17 or (TAT)6-14, explain how PCR could reveal differences (polymorphisms) among individuals. How could the Department of Justice make use of those differences?
  2. (b) Y-STRs from the nonrecombining region of the Y chromosome (NRY) have special relevance for forensic purposes. Why?
  3. (c) What would be the value of knowing the ethnic population differences for Y-STR polymorphisms?
  4. (d) For forensic applications, the probability of a “match” for a crime scene DNA sample and a suspect’s DNA often culminates in a guilty or innocent verdict. How is a “match” determined, and what are the uses and limitations of such probabilities?
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Concepts of Genetics Plus Mastering Genetics with Pearson eText -- Access Card Package (12th Edition) (What's New in Genetics)

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