GENETICS:ANALYSIS+PRIN.(LL)-W/ACCESS
6th Edition
ISBN: 9781260239775
Author: BROOKER
Publisher: MCG
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Chapter 2, Problem 6CONQ
In your own words, describe Mendel’s law of segregation. Do not use the word segregation in your answer.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
List substitutions in your diet you could make to improve it based on what you know now about a balanced diet. For instance, if you like to drink soda, you might substitute skim milk or water for some of the soft drinks you consumed. List the item you wish to replace with the new item and what you hope to accomplish with that substitution. Be sure to choose foods you know that you'd enjoy and you consider more "healthful." If you feel your diet is already balanced, describe how you accomplish your balanced intake and when you began eating this way.
Chapter 2 Solutions
GENETICS:ANALYSIS+PRIN.(LL)-W/ACCESS
Ch. 2.1 - 1. Experimental advantages of using pea plants...Ch. 2.1 - The term cross refers to an experiment in which a....Ch. 2.1 - 3. To avoid self-fertilization in his pea plants,...Ch. 2.2 - Prob. 1COMQCh. 2.2 - Prob. 2COMQCh. 2.3 - A pea plant has the genotype rrYy. How many...Ch. 2.3 - A cross is made between a pea plant that is RrYy...Ch. 2.3 - Prob. 3COMQCh. 2.4 - Which of the following would not be observed in a...Ch. 2.4 - Prob. 2COMQ
Ch. 2.5 - A cross is made between AABbCcDd and AaBbccdd...Ch. 2.5 - Prob. 2COMQCh. 2.5 - Prob. 3COMQCh. 2 - 1. Why did Mendel’s work refute the idea of...Ch. 2 - 2. What is the difference between...Ch. 2 - 3. Describe the difference between genotype and...Ch. 2 - 4. With regard to genotypes, what is a...Ch. 2 - 5. How can you determine whether an organism is...Ch. 2 - In your own words, describe Mendels law of...Ch. 2 - Based on genes in pea plants that we have...Ch. 2 - Prob. 8CONQCh. 2 - Do you know the genotype of an individual with a...Ch. 2 - 10. A cross is made between a pea plant that has...Ch. 2 - Prob. 11CONQCh. 2 - 12. Describe the significance of nonparentals with...Ch. 2 - For the following pedigrees, describe what you...Ch. 2 - Ectrodactyly, also known as lobster claw syndrome,...Ch. 2 - Identical twins are produced from the same sperm...Ch. 2 - In cocker spaniels, solid coat color is dominant...Ch. 2 - A cross was made between a white male dog and two...Ch. 2 - 18. In humans, the allele for brown eye color (B)...Ch. 2 - Albinism, a condition characterized by a partial...Ch. 2 - A true-breeding tall plant was crossed to a dwarf...Ch. 2 - 21. For pea plants with the following genotypes,...Ch. 2 - 22. An individual has the genotypeand makes an...Ch. 2 - 23. In people with maple syrup urine disease, the...Ch. 2 - Prob. 24CONQCh. 2 - 25. A true-breeding pea plant with round and Page...Ch. 2 - Prob. 26CONQCh. 2 - 27. What are the expected phenotypic ratios from...Ch. 2 - Prob. 28CONQCh. 2 - Prob. 29CONQCh. 2 - A pea plant that is dwarf with green, wrinkled...Ch. 2 - 31. A true-breeding plant with round and green...Ch. 2 - Wooly hair is a rare dominant trait found in...Ch. 2 - Huntington disease is a rare dominant trait that...Ch. 2 - 34. A woman with achondroplasia (a dominant form...Ch. 2 - 1. Describe three advantages of using pea plants...Ch. 2 - Explain the technical differences between a...Ch. 2 - 3. How long did it take Mendel to complete the...Ch. 2 - 4. For all seven characters described in the data...Ch. 2 - From the point of view of crosses and data...Ch. 2 - 6. As in many animals, albino coat color is a...Ch. 2 - 7. The fungus Melampsora lini causes a disease...Ch. 2 - For Mendels data for the experiment in Figure 2.8,...Ch. 2 - 9. Would it be possible to deduce the law of...Ch. 2 - In fruit flies, curved wings are recessive to...Ch. 2 - A recessive allele in mice results in an unusally...Ch. 2 - Prob. 12EQCh. 2 - Prob. 13EQCh. 2 - Prob. 14EQCh. 2 - 15. A cross was made between two strains of plants...Ch. 2 - A cross was made between two pea plants, TtAa and...Ch. 2 - Consider this four-factor cross: TtRryyAaTtRRYyaa,...
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